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URTICARIAL REACTION INDUCED IN THE DOG BY INTRAVENOUS INJECTION OF SORBITOL MONOLAURATE

URTICARIAL REACTION INDUCED IN THE DOG BY INTRAVENOUS INJECTION OF SORBITOL MONOLAURATE Abstract DURING the course of experiments on parenteral nutrition in the dog, H. C. Meng and Smith Freeman1 observed that the slow intravenous injection of a fat emulsion, stabilized with sorbitol monolaurate (tween 20®), was associated with the development of urticaria. This observation prompted us to undertake a study of the changes which might be related to the development of urticaria, since no other pure substance is known to us which on intravenous injection will consistently cause urticaria. The chemical does not cause urticaria when given orally but does so when introduced intradermally, without previous sensitization of the animal. In order for one to determine the relation of this experimental urticaria in the dog to that which is produced in man, it will be necessary to review briefly what is known regarding the nature of urticaria in man. SUMMARY OF KNOWLEDGE OF THE URTICARIAL REACTION The urticarial reaction consists essentially References 1. Meng, H. C., and Freeman, S.: Experimental Studies on the Intravenous Injection of Fat Emulsion into Dogs , J. Lab. & Clin. Med. 33:689-707, 1948. 2. Lewis, T.: The Blood Vessels of the Human Skin and Their Responses , London, Shaw & Sons, 1926. 3. Numa, P. G.: The Histopathology of Diseases of the Skin , New York, Macmillan and Company, 1896. 4. Kline, B. S.; Cohen, M. B., and Rudolph, J. A.: J. Allergy 3:531, 1932. 5. Berger, W., and Lang, T. J.: Ztschr. f. Hyg. u. Infektionskr. 113:206, 1936. 6. Török, L., and Hare, P.: Arch. f. Dermat. u. Syph. 65:2, 1903. 7. Abell, P. G., and Schenck, H. P.: J. Immunol. 34:195, 1938. 8. Goldschmidt, S., and M'Glone, B.: Proc. Soc. Exper. Biol. & Med. 29:827, 1932. 9. Ebbecke, U.: Klin. Wchnschr. 2:1725, 1923. 10. Hoff, F.: Ztschr. f. d. ges. exper. Med. 57:253, 1927. 11. Ferrebee, J. W., and Berliner, P. W.: Proc. Soc. Exper. Biol. & Med. 46:549, 1941. 12. Török, L.: Arch. f. Dermat. u. Syph. 53:243, 1900. 13. Stead, E. A., and Warren, J. W.: J. Clin. Investigation 23:279, 1944. 14. Rocha E. Silva, M., and Dragstedt, C. A.: J. Pharmacol. & Exper. Therap. 73:405, 1941. 15. Last, M. R., and Loew, E. R.: J. Pharmacol. & Exper. Therap. . 89:81, 1947. 16. Alexander, H. L.; Elliott, R., and Kirchner, E.: J. Invest. Dermat. 3:207, 1940. 17. Hudack, S., and McMaster, P. D.: J. Exper. Med. 56:223, 1932 18. 57:751, 1933. 19. Abramson, H. A., and Engle, M.: J. Invest. Dermat. 1:65, 1938. 20. Darsie, M. L.; Perry, S. M.; Rosenfeld, D., and Zaro, J. D.: Proc. Soc. Exper. Biol. & Med. 59:278, 1945. 21. Baker, T. W.: Histaminase in Treatment of Cold Allergy , J. A. M. A. 114:1059 ( (March 23) ) 1940. 22. Horton, B. T.; Brown, G. E., and Roth, G. M.: Hypersensitiveness to Cold, with Local and Systemic Manifestations of Histamine-Like Character: Its Amenability to Treatment , J. A. M. A. 107:1263 ( (Oct. 17) ) 1936. 23. Krogh, A.: The Anatomy and Physiology of the Capillaries , New Haven, Conn., Yale University Press, 1929. 24. Rous, P., and Gilding, B. M.: J. Exper. Med. 51:27, 1930. 25. Best, C. H., and McHenry, E. W.: Physiol. Rev. 11:379, 1931. 26. Rose, B., and Brown, J. S. L.: Am. J. Physiol. 124:412, 1938. 27. Rosenthal, S. P., and Minard, D.: J. Exper. Med. 70:415, 1939.Crossref 28. Marshall, P. B.: J. Physiol. 102:180, 1943. 29. Alexander, F.: Quart. J. Exper. Physiol. 33:71, 1944. 30. Grant, R. T.; Pearson, R. S. B., and Comeau, W. J.: Clin. Sc. 2:253, 1936. 31. Doupe, J.; Cullen, C. H.; Macaulay, L. J.; Sharp, M. E.; Barnes, R., and Kerr, A. S.: J. Neurol. & Psychiat. 6:94, 1943. 32. Tuft, L., and Brodsky, M. L.: J. Allergy 7:238, 1936. 33. Lewis, T.: Clin. Sc. 5:5, 1944. 34. Loew, C. R.: Physiol. Rev. 27:542, 1947. 35. Alexander, Elliott and Kirchner.6c Cooke, R. A.: J. Immunol. 7:219, 1922. 36. Zurhelle, E.: Dermat. Ztschr. 72:129, 1935. 37. Shaffer, B.: J. Invest. Dermat. 3:159, 1940. 38. Hare, R.: Heart 13:227, 1926. 39. Wells, J. A.; Morris, H. C.; Bull, H. B., and Dragstedt, C. A.: J. Pharmacol. & Exper. Therap. 85:122, 1945. 40. Halperin, B. N., and Mauris, G.: Compt. rend. Soc. de biol. 140:440, 1946. 41. Grob. D.; Lilienthal, J. L., and Harvey, D. M.: Bull. Johns Hopkins Hosp. 80:299, 1927. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

URTICARIAL REACTION INDUCED IN THE DOG BY INTRAVENOUS INJECTION OF SORBITOL MONOLAURATE

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References (13)

Publisher
American Medical Association
Copyright
Copyright © 1948 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1948.01520250003001
Publisher site
See Article on Publisher Site

Abstract

Abstract DURING the course of experiments on parenteral nutrition in the dog, H. C. Meng and Smith Freeman1 observed that the slow intravenous injection of a fat emulsion, stabilized with sorbitol monolaurate (tween 20®), was associated with the development of urticaria. This observation prompted us to undertake a study of the changes which might be related to the development of urticaria, since no other pure substance is known to us which on intravenous injection will consistently cause urticaria. The chemical does not cause urticaria when given orally but does so when introduced intradermally, without previous sensitization of the animal. In order for one to determine the relation of this experimental urticaria in the dog to that which is produced in man, it will be necessary to review briefly what is known regarding the nature of urticaria in man. SUMMARY OF KNOWLEDGE OF THE URTICARIAL REACTION The urticarial reaction consists essentially References 1. Meng, H. C., and Freeman, S.: Experimental Studies on the Intravenous Injection of Fat Emulsion into Dogs , J. Lab. & Clin. Med. 33:689-707, 1948. 2. Lewis, T.: The Blood Vessels of the Human Skin and Their Responses , London, Shaw & Sons, 1926. 3. Numa, P. G.: The Histopathology of Diseases of the Skin , New York, Macmillan and Company, 1896. 4. Kline, B. S.; Cohen, M. B., and Rudolph, J. A.: J. Allergy 3:531, 1932. 5. Berger, W., and Lang, T. J.: Ztschr. f. Hyg. u. Infektionskr. 113:206, 1936. 6. Török, L., and Hare, P.: Arch. f. Dermat. u. Syph. 65:2, 1903. 7. Abell, P. G., and Schenck, H. P.: J. Immunol. 34:195, 1938. 8. Goldschmidt, S., and M'Glone, B.: Proc. Soc. Exper. Biol. & Med. 29:827, 1932. 9. Ebbecke, U.: Klin. Wchnschr. 2:1725, 1923. 10. Hoff, F.: Ztschr. f. d. ges. exper. Med. 57:253, 1927. 11. Ferrebee, J. W., and Berliner, P. W.: Proc. Soc. Exper. Biol. & Med. 46:549, 1941. 12. Török, L.: Arch. f. Dermat. u. Syph. 53:243, 1900. 13. Stead, E. A., and Warren, J. W.: J. Clin. Investigation 23:279, 1944. 14. Rocha E. Silva, M., and Dragstedt, C. A.: J. Pharmacol. & Exper. Therap. 73:405, 1941. 15. Last, M. R., and Loew, E. R.: J. Pharmacol. & Exper. Therap. . 89:81, 1947. 16. Alexander, H. L.; Elliott, R., and Kirchner, E.: J. Invest. Dermat. 3:207, 1940. 17. Hudack, S., and McMaster, P. D.: J. Exper. Med. 56:223, 1932 18. 57:751, 1933. 19. Abramson, H. A., and Engle, M.: J. Invest. Dermat. 1:65, 1938. 20. Darsie, M. L.; Perry, S. M.; Rosenfeld, D., and Zaro, J. D.: Proc. Soc. Exper. Biol. & Med. 59:278, 1945. 21. Baker, T. W.: Histaminase in Treatment of Cold Allergy , J. A. M. A. 114:1059 ( (March 23) ) 1940. 22. Horton, B. T.; Brown, G. E., and Roth, G. M.: Hypersensitiveness to Cold, with Local and Systemic Manifestations of Histamine-Like Character: Its Amenability to Treatment , J. A. M. A. 107:1263 ( (Oct. 17) ) 1936. 23. Krogh, A.: The Anatomy and Physiology of the Capillaries , New Haven, Conn., Yale University Press, 1929. 24. Rous, P., and Gilding, B. M.: J. Exper. Med. 51:27, 1930. 25. Best, C. H., and McHenry, E. W.: Physiol. Rev. 11:379, 1931. 26. Rose, B., and Brown, J. S. L.: Am. J. Physiol. 124:412, 1938. 27. Rosenthal, S. P., and Minard, D.: J. Exper. Med. 70:415, 1939.Crossref 28. Marshall, P. B.: J. Physiol. 102:180, 1943. 29. Alexander, F.: Quart. J. Exper. Physiol. 33:71, 1944. 30. Grant, R. T.; Pearson, R. S. B., and Comeau, W. J.: Clin. Sc. 2:253, 1936. 31. Doupe, J.; Cullen, C. H.; Macaulay, L. J.; Sharp, M. E.; Barnes, R., and Kerr, A. S.: J. Neurol. & Psychiat. 6:94, 1943. 32. Tuft, L., and Brodsky, M. L.: J. Allergy 7:238, 1936. 33. Lewis, T.: Clin. Sc. 5:5, 1944. 34. Loew, C. R.: Physiol. Rev. 27:542, 1947. 35. Alexander, Elliott and Kirchner.6c Cooke, R. A.: J. Immunol. 7:219, 1922. 36. Zurhelle, E.: Dermat. Ztschr. 72:129, 1935. 37. Shaffer, B.: J. Invest. Dermat. 3:159, 1940. 38. Hare, R.: Heart 13:227, 1926. 39. Wells, J. A.; Morris, H. C.; Bull, H. B., and Dragstedt, C. A.: J. Pharmacol. & Exper. Therap. 85:122, 1945. 40. Halperin, B. N., and Mauris, G.: Compt. rend. Soc. de biol. 140:440, 1946. 41. Grob. D.; Lilienthal, J. L., and Harvey, D. M.: Bull. Johns Hopkins Hosp. 80:299, 1927.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Dec 1, 1948

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