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PEMPHIGUS VULGARIS: A Clinicoanatomic Study

PEMPHIGUS VULGARIS: A Clinicoanatomic Study Abstract THE TERM pemphigus is applied to a group of relapsing, usually fatal, bullous eruptions. The cause of pemphigus vulgaris remains obscure, and no specific treatment is known to be uniformly effective. Recently much discussion has centered on the role of the adrenal gland in pemphigus, together with the associated characteristic electrolyte pattern and the fluid balance,1 the results of adrenal cortex replacement therapy2 and the anatomic changes seen in the adrenal gland on postmortem examination.3 Since little attention has been directed to complete postmortem studies, the following 4 cases are reported as a contribution to the total knowledge concerning pemphigus vulgaris. REPORT OF CASES Case 1.— T. O. M., a 38 year old white male truck driver, was admitted to the hospital complaining of a "sore mouth and body rash of thirteen months' duration." He was seen by his physician at the onset of his present illness; References 1. Talbott, J. H.; Lever, W. F., and Consolario, W. V.: Metabolic Studies on Patients with Pemphigus , J. Invest. Dermat. 3:31, 1940.Crossref 2. Lever, W. F., and Talbott, J. H.: Pemphigus: A Further Report on Chemical Studies of the Blood Serum and Treatment with Adrenocortical Extract, Dihydrotachysterol or Vitamin D , New England J. Med. 231:44, 1944.Crossref 3. Goldzieher, J. W.: The Adrenal Glands in Pemphigus Vulgaris: Report of Six Autopsies and Review of Literature , Arch. Dermat. & Syph. 52:369 ( (Nov.) -Dec.) 1945 4. The Adrenal Glands in Pemphigus Vulgaris: Report of a Case , Goldzieher Arch. Dermat. & Syph. (Nov.) 53:42 (Jan.) 1946. 5. Grace, A. W., and Hellman, D. L.: Pemphigus Vulgaris: Successful Results Following Transfusion of Blood from Persons Who Have Recovered from the Disease , Arch. Dermat. & Syph. 53:249 ( (March) ) 1946. 6. Lever, W. F., and Talbott, J. H.: Pemphigus: A Clinical Analysis and Follow-Up Study of Sixty-Two Patients , Arch. Dermat. & Syph. 46:348 ( (Sept.) ) 1942. 7. Gellis, S., and Glass, F. A.: Pemphigus: A Survey of One Hundred and Seventy Patients Admitted to Bellevue Hospital from 1911 to 1941 , Arch. Dermat. & Syph. 44:321 ( (Sept.) ) 1941. 8. Eller, J. A., and Kest, L. H.: Pemphigus: Report of Seventy-Seven Cases , Arch. Dermat. & Syph. 44:337 ( (Sept.) ) 1941. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

PEMPHIGUS VULGARIS: A Clinicoanatomic Study

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References (12)

Publisher
American Medical Association
Copyright
Copyright © 1948 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1948.01520180108011
Publisher site
See Article on Publisher Site

Abstract

Abstract THE TERM pemphigus is applied to a group of relapsing, usually fatal, bullous eruptions. The cause of pemphigus vulgaris remains obscure, and no specific treatment is known to be uniformly effective. Recently much discussion has centered on the role of the adrenal gland in pemphigus, together with the associated characteristic electrolyte pattern and the fluid balance,1 the results of adrenal cortex replacement therapy2 and the anatomic changes seen in the adrenal gland on postmortem examination.3 Since little attention has been directed to complete postmortem studies, the following 4 cases are reported as a contribution to the total knowledge concerning pemphigus vulgaris. REPORT OF CASES Case 1.— T. O. M., a 38 year old white male truck driver, was admitted to the hospital complaining of a "sore mouth and body rash of thirteen months' duration." He was seen by his physician at the onset of his present illness; References 1. Talbott, J. H.; Lever, W. F., and Consolario, W. V.: Metabolic Studies on Patients with Pemphigus , J. Invest. Dermat. 3:31, 1940.Crossref 2. Lever, W. F., and Talbott, J. H.: Pemphigus: A Further Report on Chemical Studies of the Blood Serum and Treatment with Adrenocortical Extract, Dihydrotachysterol or Vitamin D , New England J. Med. 231:44, 1944.Crossref 3. Goldzieher, J. W.: The Adrenal Glands in Pemphigus Vulgaris: Report of Six Autopsies and Review of Literature , Arch. Dermat. & Syph. 52:369 ( (Nov.) -Dec.) 1945 4. The Adrenal Glands in Pemphigus Vulgaris: Report of a Case , Goldzieher Arch. Dermat. & Syph. (Nov.) 53:42 (Jan.) 1946. 5. Grace, A. W., and Hellman, D. L.: Pemphigus Vulgaris: Successful Results Following Transfusion of Blood from Persons Who Have Recovered from the Disease , Arch. Dermat. & Syph. 53:249 ( (March) ) 1946. 6. Lever, W. F., and Talbott, J. H.: Pemphigus: A Clinical Analysis and Follow-Up Study of Sixty-Two Patients , Arch. Dermat. & Syph. 46:348 ( (Sept.) ) 1942. 7. Gellis, S., and Glass, F. A.: Pemphigus: A Survey of One Hundred and Seventy Patients Admitted to Bellevue Hospital from 1911 to 1941 , Arch. Dermat. & Syph. 44:321 ( (Sept.) ) 1941. 8. Eller, J. A., and Kest, L. H.: Pemphigus: Report of Seventy-Seven Cases , Arch. Dermat. & Syph. 44:337 ( (Sept.) ) 1941.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: May 1, 1948

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