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CHEMOSURGICAL TREATMENT OF CANCER OF THE FACE: A Microscopically Controlled Method of Excision

CHEMOSURGICAL TREATMENT OF CANCER OF THE FACE: A Microscopically Controlled Method of Excision Abstract THE DEVELOPMENT of the chemosurgical method has been described,1 as has the use of the method in the treatment of cancer in specific sites such as lip,2 nose,3 ear4 and eyelid.5 This article concerns the chemosurgical treatment of cancer of the face, exclusive of the nose, ear, eyelid and vermilion portion of the lips. TECHNIC The most important feature of the chemosurgical treatment of cancer is the microscopic control of excision afforded by the technic hereinafter described.As the term "chemosurgery" suggests, the tissues are chemically treated and then surgically excised. The chemical treatment serves to produce fixation of the tissues, so that specimens may be excised for systematic microscopic examination.To illustrate the technic there will be described the chemosurgical treatment of a simple squamous cell epithelioma of the temple (fig. 1A).The following steps were taken: 1. Dichloroacetic acid was applied to References 1. Mohs, F. E., and Guyer, M. F.: Pre-Excisional Fixation of Tissues in the Treatment of Cancer in Rats , Cancer Research 1:49 ( (Jan.) ) 1941. 2. Mohs, F. E.: Chemosurgery: A Microscopically Controlled Method of Cancer Excision , Arch. Surg. 42:279 ( (Feb.) ) 1941.Crossref 3. Mohs, F. E.: Chemosurgical Treatment of Cancer of the Lip: A Microscopically Controlled Method of Excision , Arch. Surg. 48:478 ( (June) ) 1944.Crossref 4. Mohs, F. E.: Chemosurgical Treatment of Cancer of the Nose: A Microscopically Controlled Method of Excision , Arch. Surg. 53:327 ( (Sept.) ) 1946.Crossref 5. Mohs, F. E.: Chemosurgical Treatment of Cancer of the Ear: A Microscopically Controlled Method of Excision , Surgery 21:605 ( (May) ) 1947. 6. Mohs, F. E.: Chemosurgical Treatment of Cancer of the Eyelid: A Microscopically Controlled Method of Excision , Arch. Ophth. , to be published. 7. The zinc chloride fixative paste contains 40 Gm. of stibnite (80 mesh sieve). 10 Gm. of powdered sanguinaria and 34.5 cc. of a saturated solution of zinc chloride 8. Martin, H. E.; MacComb, W. S., and Blady, J. V.: Cancer of the Lip , Ann. Surg. 114:341 ( (Sept.) ) 1941.Crossref 9. Magnussen, A. H. W.: Skin Cancer: A Clinical Study with Special Reference to Radium Treatment , Acta radiol. , 1935, (supp. 22) , p. 1. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

CHEMOSURGICAL TREATMENT OF CANCER OF THE FACE: A Microscopically Controlled Method of Excision

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References (8)

Publisher
American Medical Association
Copyright
Copyright © 1947 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1947.01520080003001
Publisher site
See Article on Publisher Site

Abstract

Abstract THE DEVELOPMENT of the chemosurgical method has been described,1 as has the use of the method in the treatment of cancer in specific sites such as lip,2 nose,3 ear4 and eyelid.5 This article concerns the chemosurgical treatment of cancer of the face, exclusive of the nose, ear, eyelid and vermilion portion of the lips. TECHNIC The most important feature of the chemosurgical treatment of cancer is the microscopic control of excision afforded by the technic hereinafter described.As the term "chemosurgery" suggests, the tissues are chemically treated and then surgically excised. The chemical treatment serves to produce fixation of the tissues, so that specimens may be excised for systematic microscopic examination.To illustrate the technic there will be described the chemosurgical treatment of a simple squamous cell epithelioma of the temple (fig. 1A).The following steps were taken: 1. Dichloroacetic acid was applied to References 1. Mohs, F. E., and Guyer, M. F.: Pre-Excisional Fixation of Tissues in the Treatment of Cancer in Rats , Cancer Research 1:49 ( (Jan.) ) 1941. 2. Mohs, F. E.: Chemosurgery: A Microscopically Controlled Method of Cancer Excision , Arch. Surg. 42:279 ( (Feb.) ) 1941.Crossref 3. Mohs, F. E.: Chemosurgical Treatment of Cancer of the Lip: A Microscopically Controlled Method of Excision , Arch. Surg. 48:478 ( (June) ) 1944.Crossref 4. Mohs, F. E.: Chemosurgical Treatment of Cancer of the Nose: A Microscopically Controlled Method of Excision , Arch. Surg. 53:327 ( (Sept.) ) 1946.Crossref 5. Mohs, F. E.: Chemosurgical Treatment of Cancer of the Ear: A Microscopically Controlled Method of Excision , Surgery 21:605 ( (May) ) 1947. 6. Mohs, F. E.: Chemosurgical Treatment of Cancer of the Eyelid: A Microscopically Controlled Method of Excision , Arch. Ophth. , to be published. 7. The zinc chloride fixative paste contains 40 Gm. of stibnite (80 mesh sieve). 10 Gm. of powdered sanguinaria and 34.5 cc. of a saturated solution of zinc chloride 8. Martin, H. E.; MacComb, W. S., and Blady, J. V.: Cancer of the Lip , Ann. Surg. 114:341 ( (Sept.) ) 1941.Crossref 9. Magnussen, A. H. W.: Skin Cancer: A Clinical Study with Special Reference to Radium Treatment , Acta radiol. , 1935, (supp. 22) , p. 1.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Aug 1, 1947

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