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PEMPHIGUS VULGARIS: A Study of the Blood Picture

PEMPHIGUS VULGARIS: A Study of the Blood Picture Abstract CLINICAL and laboratory studies have led me to believe that pemphigus vulgaris is a generalized infection.1 Evidence to support this belief was sought by an examination of the blood picture and is presented in this paper. Generalized infections produce qualitative and quantitative alterations in the blood picture, which include (a) leukocytosis, which is generally due to an increase in the number of cells of the polymorphonuclear series; (b) changes in the polymorphonuclear leukocytes (these include an increase in the proportion of immature and a corresponding decrease in that of the mature cells; the severer the degree of infection or toxemia resulting from infection, the higher is the proportion of immature cells; in this paper the term "immature" is used to designate the polymorphonuclear leukocytes in which the nucleus is indented but not segmented and also Schilling's staff forms with unsegmented nuclei, which may be in the shape of a References 1. Grace, A. W.: Pemphigus: Effect of Pemphigus Serum on the Leukocytic Picture of Rabbits , Arch. Dermat. & Syph. 29:885 ( (June) ) 1934; 2. Pemphigus: Evidence in Support of a Bacteremia as an Explanation of Certain Terminal Changes in the Blood Picture , Grace Arch. Dermat. & Syph. 30:22 ( (July) ) 1934. 3. Grace, A. W., and Suskind, F. H.: An Agent, Transmissible to Mice, Obtained During a Study of Pemphigus Vulgaris , Proc. Soc. Exper. Biol. & Med. 37:324, 1937. 4. Grace, A. W.: Pemphigus , M. Clin. North America 22:1345, 1938. 5. Grace, A. W., and Suskind, F. H.: An Investigation of the Etiology of Pemphigus Vulgaris , J. Invest. Dermat. 2:1, 1939. 6. Wintrobe, M. M.: Clinical Hematology , Philadelphia, Lea & Febiger, 1942, p. 98. 7. Wintrobe,2 p. 123. 8. Piney, A.: Recent Advances in Haematology , ed. 3, Philadelphia, P. Blakiston's Son & Co., 1931, p. 143. 9. Wintrobe,2 p. 72. 10. Wintrobe,2 p. 125. 11. Grace, A. W.: The Etiologic Agent of Pemphigus Vulgaris , Bull. New York Acad. Med. 22:480 ( (Sept.) ) 1946. 12. Wintrobe,2 p. 132. 13. Wintrobe,2 p. 116. 14. Grace, A. W.: The Significance of Eosinophilia in Blister Fluid and Peripheral Blood in Pemphigus Vulgaris, to be published. 15. Wintrobe,2 p. 117. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

PEMPHIGUS VULGARIS: A Study of the Blood Picture

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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1947 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1947.01520060034004
Publisher site
See Article on Publisher Site

Abstract

Abstract CLINICAL and laboratory studies have led me to believe that pemphigus vulgaris is a generalized infection.1 Evidence to support this belief was sought by an examination of the blood picture and is presented in this paper. Generalized infections produce qualitative and quantitative alterations in the blood picture, which include (a) leukocytosis, which is generally due to an increase in the number of cells of the polymorphonuclear series; (b) changes in the polymorphonuclear leukocytes (these include an increase in the proportion of immature and a corresponding decrease in that of the mature cells; the severer the degree of infection or toxemia resulting from infection, the higher is the proportion of immature cells; in this paper the term "immature" is used to designate the polymorphonuclear leukocytes in which the nucleus is indented but not segmented and also Schilling's staff forms with unsegmented nuclei, which may be in the shape of a References 1. Grace, A. W.: Pemphigus: Effect of Pemphigus Serum on the Leukocytic Picture of Rabbits , Arch. Dermat. & Syph. 29:885 ( (June) ) 1934; 2. Pemphigus: Evidence in Support of a Bacteremia as an Explanation of Certain Terminal Changes in the Blood Picture , Grace Arch. Dermat. & Syph. 30:22 ( (July) ) 1934. 3. Grace, A. W., and Suskind, F. H.: An Agent, Transmissible to Mice, Obtained During a Study of Pemphigus Vulgaris , Proc. Soc. Exper. Biol. & Med. 37:324, 1937. 4. Grace, A. W.: Pemphigus , M. Clin. North America 22:1345, 1938. 5. Grace, A. W., and Suskind, F. H.: An Investigation of the Etiology of Pemphigus Vulgaris , J. Invest. Dermat. 2:1, 1939. 6. Wintrobe, M. M.: Clinical Hematology , Philadelphia, Lea & Febiger, 1942, p. 98. 7. Wintrobe,2 p. 123. 8. Piney, A.: Recent Advances in Haematology , ed. 3, Philadelphia, P. Blakiston's Son & Co., 1931, p. 143. 9. Wintrobe,2 p. 72. 10. Wintrobe,2 p. 125. 11. Grace, A. W.: The Etiologic Agent of Pemphigus Vulgaris , Bull. New York Acad. Med. 22:480 ( (Sept.) ) 1946. 12. Wintrobe,2 p. 132. 13. Wintrobe,2 p. 116. 14. Grace, A. W.: The Significance of Eosinophilia in Blister Fluid and Peripheral Blood in Pemphigus Vulgaris, to be published. 15. Wintrobe,2 p. 117.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Jun 1, 1947

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