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USE OF BENADRYL FOR URTICARIA AND RELATED DERMATOSES: A PRELIMINARY REPORT

USE OF BENADRYL FOR URTICARIA AND RELATED DERMATOSES: A PRELIMINARY REPORT Abstract Symptomatic relief of urticaria and allied manifestations of cutaneous allergy is essential to the management of such dermatoses while a search for their cause is being made. The use of epinephrine, ephedrine and sedatives is often contraindicated or unsatisfactory. Attempts at desensitization to histamine have proved disappointing. We are therefore making this preliminary report to call attention to a new drug which shows promise, we believe, in the management of such eruptions. PHARMACOLOGY Benadryl1 (beta dimethylaminoethyl benzhydryl ether hydrochloride) antagonizes the effects of histamine on smooth muscle of the bronchioles and intestines of guinea pigs and effectively alleviates histamine shock in these animals.2 It is a white crystalline powder, soluble in water and alcohol, and is stable under ordinary conditions of temperature and atmosphere. The preparation is well tolerated by animals in many times the dosage recommended for man. The maximum response occurs References 1. Developed and supplied for clinical trial by Parke, Davis & Company, Detroit. 2. Loew, E. R.; Kaiser, M. E., and Moore, V.: Synthetic Benzhydryl Alkamine Ethers Effective in Preventing Fatal Experimental Asthma in Guinea Pigs Subjected to Vaporized Histamine , J. Pharmacol. & Exper. Therap. , to be published. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

USE OF BENADRYL FOR URTICARIA AND RELATED DERMATOSES: A PRELIMINARY REPORT

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References (1)

Publisher
American Medical Association
Copyright
Copyright © 1945 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1945.01510280027004
Publisher site
See Article on Publisher Site

Abstract

Abstract Symptomatic relief of urticaria and allied manifestations of cutaneous allergy is essential to the management of such dermatoses while a search for their cause is being made. The use of epinephrine, ephedrine and sedatives is often contraindicated or unsatisfactory. Attempts at desensitization to histamine have proved disappointing. We are therefore making this preliminary report to call attention to a new drug which shows promise, we believe, in the management of such eruptions. PHARMACOLOGY Benadryl1 (beta dimethylaminoethyl benzhydryl ether hydrochloride) antagonizes the effects of histamine on smooth muscle of the bronchioles and intestines of guinea pigs and effectively alleviates histamine shock in these animals.2 It is a white crystalline powder, soluble in water and alcohol, and is stable under ordinary conditions of temperature and atmosphere. The preparation is well tolerated by animals in many times the dosage recommended for man. The maximum response occurs References 1. Developed and supplied for clinical trial by Parke, Davis & Company, Detroit. 2. Loew, E. R.; Kaiser, M. E., and Moore, V.: Synthetic Benzhydryl Alkamine Ethers Effective in Preventing Fatal Experimental Asthma in Guinea Pigs Subjected to Vaporized Histamine , J. Pharmacol. & Exper. Therap. , to be published.

Journal

Archives of Dermatology and Syphilology – American Medical Association

Published: Oct 1, 1945

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