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RAPID TREATMENT OF EARLY SYPHILIS WITH SMALL DOSES OF PENICILLIN: OBSERVATIONS IN ONE HUNDRED AND FIFTY-NINE CASES

RAPID TREATMENT OF EARLY SYPHILIS WITH SMALL DOSES OF PENICILLIN: OBSERVATIONS IN ONE HUNDRED AND... Abstract Since the report by Mahoney, Arnold and Harris1 that penicillin is effective as a chemotherapeutic agent for early syphilis, the members of the medical profession have been eagerly awaiting appraisal of this drug. A subsequent report was given by Mahoney and his group2 and a preliminary report by Moore and his associates3 on the results of the treatment of early syphilis by members of the penicillin panel.4 The panel, recognizing the necessity of determining optimal dosage and time schedules, assigned the University Hospital and the Cleveland City Hospital the schedules of treatment herein reported on as part of a larger investigation. Before participating in the studies of the penicillin panel, we obtained sufficient penicillin for the treatment of 10 patients with early dark field-positive syphilis in October 1943.5 The first 5 patients received 400,000 units of the drug intravenously in References 1. Mahoney, J. F.; Arnold, R. C., and Harris, A.: Penicillin Treatment of Early Syphilis , Am. J. Pub. Health 33:1387 ( (Dec.) ) 1943. 2. Mahoney, J. F.; Arnold, R. C.; Sterner, B. L.; Harris, A., and Zwally, M. R.: Penicillin Treatment of Early Syphilis , J. A. M. A. 126:63 ( (Sept. 9) ) 1944.Crossref 3. Moore, J. E.; Mahoney, J. F.; Schwartz, W.; Sternberg, T., and Wood, W. B.: The Treatment of Early Syphilis with Penicillin , J. A. M. A. 126:67 ( (Sept. 9) ) 1944.Crossref 4. Penicillin panel of the subcommittee on Venereal Diseases, National Research Council. 5. The penicillin was provided by the Office of Scientific Research and Development from supplies assigned by the Committee on Medical Research for clinical investigations recommended by the Committee on Chemotherapeutics and Other Agents of the National Research Council. 6. Dunham, W. B.; Hamre, D. M.; McKee, C. M., and Rake, G.: Action of Penicillin and Other Antibiotics on Treponema Pallidum , Proc. Soc. Exper. Biol. & Med. 55:158 ( (March) ) 1944. 7. Beyer, K. H.; Woodward, R.; Peters, L.; Verwey, W. F., and Mattis, P. A.: Prolongation of Penicillin Retention in Body by Means of Para-Aminohippuric Acid , Science 100:107 ( (Aug. 4) ) 1944. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

RAPID TREATMENT OF EARLY SYPHILIS WITH SMALL DOSES OF PENICILLIN: OBSERVATIONS IN ONE HUNDRED AND FIFTY-NINE CASES

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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1945 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1945.01510210042010
Publisher site
See Article on Publisher Site

Abstract

Abstract Since the report by Mahoney, Arnold and Harris1 that penicillin is effective as a chemotherapeutic agent for early syphilis, the members of the medical profession have been eagerly awaiting appraisal of this drug. A subsequent report was given by Mahoney and his group2 and a preliminary report by Moore and his associates3 on the results of the treatment of early syphilis by members of the penicillin panel.4 The panel, recognizing the necessity of determining optimal dosage and time schedules, assigned the University Hospital and the Cleveland City Hospital the schedules of treatment herein reported on as part of a larger investigation. Before participating in the studies of the penicillin panel, we obtained sufficient penicillin for the treatment of 10 patients with early dark field-positive syphilis in October 1943.5 The first 5 patients received 400,000 units of the drug intravenously in References 1. Mahoney, J. F.; Arnold, R. C., and Harris, A.: Penicillin Treatment of Early Syphilis , Am. J. Pub. Health 33:1387 ( (Dec.) ) 1943. 2. Mahoney, J. F.; Arnold, R. C.; Sterner, B. L.; Harris, A., and Zwally, M. R.: Penicillin Treatment of Early Syphilis , J. A. M. A. 126:63 ( (Sept. 9) ) 1944.Crossref 3. Moore, J. E.; Mahoney, J. F.; Schwartz, W.; Sternberg, T., and Wood, W. B.: The Treatment of Early Syphilis with Penicillin , J. A. M. A. 126:67 ( (Sept. 9) ) 1944.Crossref 4. Penicillin panel of the subcommittee on Venereal Diseases, National Research Council. 5. The penicillin was provided by the Office of Scientific Research and Development from supplies assigned by the Committee on Medical Research for clinical investigations recommended by the Committee on Chemotherapeutics and Other Agents of the National Research Council. 6. Dunham, W. B.; Hamre, D. M.; McKee, C. M., and Rake, G.: Action of Penicillin and Other Antibiotics on Treponema Pallidum , Proc. Soc. Exper. Biol. & Med. 55:158 ( (March) ) 1944. 7. Beyer, K. H.; Woodward, R.; Peters, L.; Verwey, W. F., and Mattis, P. A.: Prolongation of Penicillin Retention in Body by Means of Para-Aminohippuric Acid , Science 100:107 ( (Aug. 4) ) 1944.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Mar 1, 1945

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