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ACANTHOSIS NIGRICANS: IS IT A FORM OF AVITAMINOSIS?

ACANTHOSIS NIGRICANS: IS IT A FORM OF AVITAMINOSIS? Abstract Acanthosis nigricans is a puzzling and rare but distinctive disease of the skin and the mucous membranes. Of its characteristics, it is the striking appearance which has occasioned the many observations which have been made and reported. The characteristic features are changes in pigmentation, both increases and decreases; the appearance of vegetative warty growths; dystrophy and even loss of hair and nails; papillation 1 about the mucocutaneous junctions of the mouth, eyelids, external genitalia and perianal area, and itching of variable character, which at times is unbelievably intense. As a general rule, two types are recognized. One is the benign juvenile form, which occurs in children and which is usually of little consequence, as it bears no relation to the general well-being. The other is the adult type, which in the vast majority of instances occurs in cachetic persons who suffer from carcinoma of the stomach or intestines, sarcoma, severe References 1. Sutton, R. L., and Sutton, R. L., Jr.: Diseases of the Skin , ed. 10, St. Louis, C. V. Mosby Company, 1939, p. 1507. 2. Pollitzer, in Internationaler Atlas seltener Hautkrankheiten , Leipzig, 1890 3. Acanthosis Nigricans: A Symptom of Disorder of the Abdominal Sympathetic , J. A. M. A. 53:1369 ( (Oct. 23) ) 1909. 4. Janovsky, in Internationaler Atlas seltener Hautkrankheiten , Leipzig, 1890. 5. Unna, cited by MacLeod, J. M. H.: Diseases of the Skin , New York, Paul B. Hoeber, 1921, p. 1100. 6. Darier, J.: Ann. de dermat. et syph. 4:865, 1893. 7. Yearbook of Dermatology and Syphilology , Practical Medicine Series, Chicago, Year Book Publishers, Inc., 1914, vol. 9, p. 13. 8. Masson, J. C., and Montgomery, H.: Am. J. Obst. & Gynec. 32:717, 1936. 9. Petrini de Galatz: Ann. de dermat. et syph. 5:321, 1914. 10. Wise, F.: J. Cutan. Dis. 36:35, 1918. 11. Knowles, F. C.; Sidlick, D. M., and Ludy, J. B.: Acanthosis Nigricans: Adult and Juvenile Types , Arch. Dermat. & Syph. 19:391 ( (March) ) 1929. 12. Curth, H.: Benign Type of Acanthosis Nigricans: Etiology , Arch. Dermat. & Syph. 34:353 ( (Sept.) ) 1936. 13. Hellerström, S.: Acta dermat.-venereol. 14:86, 1933. 14. Grace, A. W., and Schwartz, H. J.: Acanthosis Nigricans: Case of Benign Form in Adult Investigated from Aspect of Endocrine Dysfunction , Arch. Dermat. & Syph. 29:691 ( (May) ) 1934. 15. Darier, J.: Ann. de dermat. et syph. 4:421, 1893. 16. Bloch, cited by Ewing.16 17. Ewing, J.: Neoplastic Diseases , ed. 4, Philadelphia, W. B. Saunders Company, 1941, p. 891. 18. Alkiewicz, J.: Arch. f. Dermat. u. Syph. 168:522, 1933. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

ACANTHOSIS NIGRICANS: IS IT A FORM OF AVITAMINOSIS?

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References (13)

Publisher
American Medical Association
Copyright
Copyright © 1943 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1943.01510060074010
Publisher site
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Abstract

Abstract Acanthosis nigricans is a puzzling and rare but distinctive disease of the skin and the mucous membranes. Of its characteristics, it is the striking appearance which has occasioned the many observations which have been made and reported. The characteristic features are changes in pigmentation, both increases and decreases; the appearance of vegetative warty growths; dystrophy and even loss of hair and nails; papillation 1 about the mucocutaneous junctions of the mouth, eyelids, external genitalia and perianal area, and itching of variable character, which at times is unbelievably intense. As a general rule, two types are recognized. One is the benign juvenile form, which occurs in children and which is usually of little consequence, as it bears no relation to the general well-being. The other is the adult type, which in the vast majority of instances occurs in cachetic persons who suffer from carcinoma of the stomach or intestines, sarcoma, severe References 1. Sutton, R. L., and Sutton, R. L., Jr.: Diseases of the Skin , ed. 10, St. Louis, C. V. Mosby Company, 1939, p. 1507. 2. Pollitzer, in Internationaler Atlas seltener Hautkrankheiten , Leipzig, 1890 3. Acanthosis Nigricans: A Symptom of Disorder of the Abdominal Sympathetic , J. A. M. A. 53:1369 ( (Oct. 23) ) 1909. 4. Janovsky, in Internationaler Atlas seltener Hautkrankheiten , Leipzig, 1890. 5. Unna, cited by MacLeod, J. M. H.: Diseases of the Skin , New York, Paul B. Hoeber, 1921, p. 1100. 6. Darier, J.: Ann. de dermat. et syph. 4:865, 1893. 7. Yearbook of Dermatology and Syphilology , Practical Medicine Series, Chicago, Year Book Publishers, Inc., 1914, vol. 9, p. 13. 8. Masson, J. C., and Montgomery, H.: Am. J. Obst. & Gynec. 32:717, 1936. 9. Petrini de Galatz: Ann. de dermat. et syph. 5:321, 1914. 10. Wise, F.: J. Cutan. Dis. 36:35, 1918. 11. Knowles, F. C.; Sidlick, D. M., and Ludy, J. B.: Acanthosis Nigricans: Adult and Juvenile Types , Arch. Dermat. & Syph. 19:391 ( (March) ) 1929. 12. Curth, H.: Benign Type of Acanthosis Nigricans: Etiology , Arch. Dermat. & Syph. 34:353 ( (Sept.) ) 1936. 13. Hellerström, S.: Acta dermat.-venereol. 14:86, 1933. 14. Grace, A. W., and Schwartz, H. J.: Acanthosis Nigricans: Case of Benign Form in Adult Investigated from Aspect of Endocrine Dysfunction , Arch. Dermat. & Syph. 29:691 ( (May) ) 1934. 15. Darier, J.: Ann. de dermat. et syph. 4:421, 1893. 16. Bloch, cited by Ewing.16 17. Ewing, J.: Neoplastic Diseases , ed. 4, Philadelphia, W. B. Saunders Company, 1941, p. 891. 18. Alkiewicz, J.: Arch. f. Dermat. u. Syph. 168:522, 1933.

Journal

Archives of Dermatology and Syphilology – American Medical Association

Published: Dec 1, 1943

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