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EFFECT OF ANDROGEN ON THE SEBACEOUS GLANDS OF HUMAN SKIN

EFFECT OF ANDROGEN ON THE SEBACEOUS GLANDS OF HUMAN SKIN Abstract Physiologic changes in certain areas of the skin at puberty and clinical observations on the skin in cases of eunuchoidism, castration, masculinizing tumors of the ovary and pubertas praecox suggested long ago that sex hormones may in some way be involved in the control of the growth of hair and of the texture of the skin. More recently, as crystalline estrogenic and androgenic substances became available for experimental as well as therapeutic use, efforts were made to disclose effects of these substances on the skin more exactly and in more detail. Thus, valuable information was obtained concerning general effects of estrogenic and androgenic substances on growth of hair in the rat, dog and guinea pig1 as well as in man,2 and on the blood vessels of the skin in man.3 Since the skin is a complex organ and growth of hair a highly complicated process, the References 1. Zondek, B.: Inhibitory Effect of Follicular Hormone on Anterior Lobe of Pituitary Gland , Lancet 1:10 ( (April 4) ) 1936.Crossref 2. Gardner, W. U., and DeVita, J.: Inhibition of Hair Growth in Dogs Receiving Estrogen , Yale J. Biol. & Med. 13:213 ( (Dec.) ) 1940. 3. von Wattenwyl, H.: Die Wirkung subkutan implantierter Oestradioltabletten auf das Haarkleid des Meerschweinchens , Schweiz. med. Wchnschr. 71:1331 ( (Oct. 25) ) 1941. 4. Hamilton, J. B.: (a) Treatment of Sexual Underdevelopment with Synthetic Male Hormone Substance , Endocrinology 21:649 ( (Sept.) ) 1937 5. Male Hormone Substance: Prime Factor in Acne , J. Clin. Endocrinol. 1:570 ( (July) ) 1941. 6. Reynolds, S. R. M., and others: Dermovascular Action of Certain Steroid Hormones in Castrates, Eunuchoid, and Normal Men , J. Clin. Endocrinol. 2:228 ( (April) ) 1942. 7. Hooker, C. W., and Pfeiffer, C. A.: Effects of Sex Hormones upon Body Growth, Skin, Hair and Sebaceous Glands in the Rat , Endocrinology 32:69 ( (Jan.) ) 1943. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

EFFECT OF ANDROGEN ON THE SEBACEOUS GLANDS OF HUMAN SKIN

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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1943 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1943.01510060025002
Publisher site
See Article on Publisher Site

Abstract

Abstract Physiologic changes in certain areas of the skin at puberty and clinical observations on the skin in cases of eunuchoidism, castration, masculinizing tumors of the ovary and pubertas praecox suggested long ago that sex hormones may in some way be involved in the control of the growth of hair and of the texture of the skin. More recently, as crystalline estrogenic and androgenic substances became available for experimental as well as therapeutic use, efforts were made to disclose effects of these substances on the skin more exactly and in more detail. Thus, valuable information was obtained concerning general effects of estrogenic and androgenic substances on growth of hair in the rat, dog and guinea pig1 as well as in man,2 and on the blood vessels of the skin in man.3 Since the skin is a complex organ and growth of hair a highly complicated process, the References 1. Zondek, B.: Inhibitory Effect of Follicular Hormone on Anterior Lobe of Pituitary Gland , Lancet 1:10 ( (April 4) ) 1936.Crossref 2. Gardner, W. U., and DeVita, J.: Inhibition of Hair Growth in Dogs Receiving Estrogen , Yale J. Biol. & Med. 13:213 ( (Dec.) ) 1940. 3. von Wattenwyl, H.: Die Wirkung subkutan implantierter Oestradioltabletten auf das Haarkleid des Meerschweinchens , Schweiz. med. Wchnschr. 71:1331 ( (Oct. 25) ) 1941. 4. Hamilton, J. B.: (a) Treatment of Sexual Underdevelopment with Synthetic Male Hormone Substance , Endocrinology 21:649 ( (Sept.) ) 1937 5. Male Hormone Substance: Prime Factor in Acne , J. Clin. Endocrinol. 1:570 ( (July) ) 1941. 6. Reynolds, S. R. M., and others: Dermovascular Action of Certain Steroid Hormones in Castrates, Eunuchoid, and Normal Men , J. Clin. Endocrinol. 2:228 ( (April) ) 1942. 7. Hooker, C. W., and Pfeiffer, C. A.: Effects of Sex Hormones upon Body Growth, Skin, Hair and Sebaceous Glands in the Rat , Endocrinology 32:69 ( (Jan.) ) 1943.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Dec 1, 1943

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