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R. Tompsett, W. Downs, W. Mcdermott, B. Webster (1941)
THE USE OF CLORARSEN IN THE TREATMENT OF SYPHILISJournal of Pharmacology and Experimental Therapeutics, 73
A. Tatum, G. Cooper (1932)
META-AMINO PARA-HYDROXY PHENYL ARSINE OXIDE AS AN ANTISYPHILITIC AGENT.Science, 75 1951
O. Foerster, R. McIntosh, L. Wieder, H. Foerster, G. Cooper (1935)
MAPHARSEN IN THE TREATMENT OF SYPHILIS: A PRELIMINARY REPORTArchives of Dermatology, 32
J. H. Stokes , H. Beerman (1941)
The Trivalent Arsenicals in SyphilisAm. J. M. Sc., 201
O. H. Foerster , R. L. McIntosh, L. M. Weider, L. M. Foerster (1935)
Mapharsen in the Treatment of syphilisArch. Dermat. & Syph., 32
P. Ehrlich, S. Hata
Die experimentelle Chemotherapie der Spirillosen (Syphilis, Rückfallfieber, Hühnerspirillose, Frambosie)
P. Ehrlich (1910)
Die experimentelle Chemotherapie der Spirillosen
H. Cole, R. Palmer (1937)
Mapharsen in Treatment of Syphilis.British medical journal, 1 3918
J. E. Moore (1941)
The Modern Treatment of Syphilis
A. L. Tatum (1934)
An Experimental Study of Mapharsen (Meta-Amino Para-Hydroxy Phenyl Arsine Oxide) as an Antisyphilitic AgentJ. Pharmacol. & Exper. Therap., 50
Abstract The therapeutic efficiency of any arsenical preparation for the treatment of syphilis is judged largely from the response of early syphilis (primary and secondary) to its use. In order to evaluate a new drug the most important factors to consider are: (1) the rapid control of infectiousness, (2) the healing of lesions, (3) the rate and permanence of serologic response, (4) the prevention of infectious or serologic relapse and progression of the disease, (5) low incidence of involvement of the central nervous system in early syphilis, (6) a beneficial effect on late syphilis and (7) a low incidence of untoward or toxic reactions. A drug which would meet these requirements would indeed be ideal. Arsphenamine is, even today, the most active of the arsenical preparations in common use, and yet, because of the difficulties encountered in its administration and its untoward effects, it has been largely replaced by drugs which References 1. Tatum, A. L., and Cooper, G. A.: An Experimental Study of Mapharsen (Meta-Amino Para-Hydroxy Phenyl Arsine Oxide) as an Antisyphilitic Agent , J. Pharmacol. & Exper. Therap. 50:198 ( (Feb.) ) 1934. 2. Foerster, O. H.; McIntosh, R. L.; Weider, L. M.; Foerster, L. M., and Cooper, G. A.: Mapharsen in the Treatment of syphilis , Arch. Dermat. & Syph. 32:868 ( (Dec.) ) 1935. 3. Ehrlich, P., and Hata, S.: Die experimentelle Chemotherapie der Spirillosen , Berlin, Julius Springer, 1910. 4. Stokes, J. H.; Beerman, H., and Ingrem, N. R., Jr.: The Trivalent Arsenicals in Syphilis , Am. J. M. Sc. 201:611 ( (April) ) 1941. 5. Tompsett, R. R.; Downs, W. G.; McDermott, W., and Webster, B.: The Use of Clorarsen in the Treatment of Syphilis , J. Pharmacol. & Exper. Therap. 73:412 ( (Dec.) ) 1941. 6. Moore, J. E.: The Modern Treatment of Syphilis , Springfield, Ill., Charles C Thomas, Publisher, 1941, chap. 31 , p. 346.
Archives of Dermatology and Syphilology – American Medical Association
Published: Feb 1, 1943
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