Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

HISTOCHEMICAL OBSERVATIONS ON MELANIN PRODUCTION IN THE SKIN

HISTOCHEMICAL OBSERVATIONS ON MELANIN PRODUCTION IN THE SKIN Abstract For a quarter of a century studies of the problem of human pigment have been dominated by the histochemical reaction of Bloch, the dopa reaction. The importance of this reaction lies in the apparently established fact that its production denotes for the cell in question (we here ignore nonspecific reactions seen in leukocytes and sweat gland parenchyma) the capacity to make physiologic melanin. This significance for this reaction has been achieved through an endless number of studies with both animal and human skin, revealing a positive correlation between positive dopa reactions and the recognized capacity of the reacting epidermal cells to form physiologic melanin. Even more convincing has been the stronger positive correlation between the negative dopa reactions and the failure through functional perversion and damage of identical sites of skin to form pigment as disclosed clinically and histologically. While there has been this general acceptance of the dopa reaction http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

HISTOCHEMICAL OBSERVATIONS ON MELANIN PRODUCTION IN THE SKIN

Loading next page...
 
/lp/american-medical-association/histochemical-observations-on-melanin-production-in-the-skin-jbhIU6iAON

References (0)

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
American Medical Association
Copyright
Copyright © 1942 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1942.01500070107007
Publisher site
See Article on Publisher Site

Abstract

Abstract For a quarter of a century studies of the problem of human pigment have been dominated by the histochemical reaction of Bloch, the dopa reaction. The importance of this reaction lies in the apparently established fact that its production denotes for the cell in question (we here ignore nonspecific reactions seen in leukocytes and sweat gland parenchyma) the capacity to make physiologic melanin. This significance for this reaction has been achieved through an endless number of studies with both animal and human skin, revealing a positive correlation between positive dopa reactions and the recognized capacity of the reacting epidermal cells to form physiologic melanin. Even more convincing has been the stronger positive correlation between the negative dopa reactions and the failure through functional perversion and damage of identical sites of skin to form pigment as disclosed clinically and histologically. While there has been this general acceptance of the dopa reaction

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Jan 1, 1942

There are no references for this article.