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KLINE EXCLUSION TEST IN PREVENTION OF TRANSFUSION SYPHILIS

KLINE EXCLUSION TEST IN PREVENTION OF TRANSFUSION SYPHILIS Abstract The proper selection of a blood donor necessitates not only tests for compatibility of blood and physical examinations but also, immediately before the transfusion, a very sensitive blood test for syphilis to prevent the transmission of this disease. The Kline exclusion slide test is an excellent method for this purpose, even in emergency cases, because of the rapidity, simplicity and ease of its performance and its high degree of sensitivity. Fifty-nine cases1 in which syphilis has been transmitted by donors are already recorded in medical literature! The actual number is probably much greater. In most of the cases reported serologic and physical examinations of the donors either were not made at all or else were not made within from three to twelve weeks prior to the transfusion. Professional donors, especially those used in cases of emergency, usually fall in the latter category, while voluntary donors, especially friends and relatives, References 1. Jones, H. W.; Rathmell, T. K., and Wagner, C.: The Transmission of Syphilis by Blood Transfusion , Am. J. Syph. & Neurol. 19:30-38 ( (Jan.) ) 1935. 2. Brem, W. V., in discussion on Griffin, H. Z., and Haines, S. F.: A Review of a Group of Professional Donors , J. A. M. A. 81:532 ( (Aug. 18) ) 1923. 3. Périn, L., and Lefèvre, M.: Transmission de la syphilis par voie sanguine , Nourrisson 23:371-374 ( (Nov.) ) 1935. 4. Mandelbaum, H., and Saperstein, A. N.: Transmission of Syphilis by Blood Transfusion: Case of Acute Gummatous Osteomyelitis , J. A. M. A. 106:1061-1063 ( (March 28) ) 1936. 5. Polayes, S. H., and Lederer, M.: The Transmission of Syphilis by Blood Transfusion , Am. J. Syph. 15:72-80 ( (Jan.) ) 1931. 6. Post, C. D., and Cooney, G. C.: Accidental Transmission of Syphilis by Blood Transfusion , J. A. M. A. 100:258-259 ( (Jan. 28) ) 1933. 7. Feldman, V. J.: Syphilis D'Emblée , Arch. Dermat. & Syph. 18:380-382 ( (Sept.) ) 1928. 8. Cummer, C. L.: Transfusion Syphilis , Am. J. M. Sc. 185:787-789 ( (June) ) 1933. 9. Morgan, H. J.: Factors Conditioning the Transmission of Syphilis by Blood Transfusion , Am. J. M. Sc. 189:808-813 ( (June) ) 1935. 10. Williamson, G. R., and Strong, R. A.: Congenital Syphilis from Blood Transfusion to the Mother During Pregnancy , Am. J. Syph. 17:484-491 ( (Oct.) ) 1933. 11. Hendrick, H.: Diseases Transmitted in Blood Transfusion , Proc. Inst. Med. Chicago 10:185-195 ( (Jan. 15) ) 1935. 12. Aubertin, C., and Fleury, J.: Syphilis après transfusion sanguine , Bull. et mém. Soc. méd. d. hôp. de Paris 54:69-75 ( (Jan. 27) ) 1930. 13. Martin, H. E., and Whyte, R.: Organization of Transfusion Service and Blood Donors Bureau for Average Hospital , Am. J. Surg. 32:439-444 ( (June) ) 1936. 14. Corwin, E. H. L.: Community Control of Professional Blood Donors , New York State J. Med. 35:317-320 ( (April 1) ) 1935. 15. Keynes, G.: The Technique of Blood Transfusion and the Organization of a Public Transfusion Service , J. State Med. 41:685-707 ( (Dec.) ) 1933. 16. Organization of Blood Donors in Germany, Foreign Letters , J. A. M. A. 105:610-611 ( (Aug. 24) ) 1935. 17. McNamara, W. L.: The Noninfectivity of the Blood in Tertiary Syphilis , Am. J. Syph. 9:470-478 ( (July) ) 1925. 18. Jones.1a Feldman.1g Cummer.1h Hendrick.1k 19. Eller, J. J., and Rein, C. R.: Kline Finger Blood Precipitation Test for Syphilis , Arch. Dermat. & Syph. 25:238-244 ( (Feb.) ) 1932. 20. Cumming, H. S.; Hazen, H. H.; Sanford, A. H.; Senear, F. E. M.; Simpson, W. M., and Vonderlehr, R. A.: The Evaluation of Serodiagnostic Tests for Syphilis in the United States , Ven. Dis. Inform. 16:189-201 ( (June) ) 1935 21. supp. 1, June 1935, pp. 1-49. 22. Kline, B. S.: Microscopic Slide Precipitation Tests for the Diagnosis and Exclusion of Syphilis , Baltimore, Williams & Wilkins Company, 1932. 23. Rein, C. R.: The Value of the Kline Exclusion Test in the Serodiagnosis of Syphilis , Am. J. Syph., Gonor. & Ven. Dis. 20:515-522 ( (Sept.) ) 1936. 24. Rein, C. R.: Personal communication to the author on the certification of blood donors in Jamaica, N. Y. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

KLINE EXCLUSION TEST IN PREVENTION OF TRANSFUSION SYPHILIS

STRAUS, R.
Archives of Dermatology and Syphilology , Volume 36 (5) – Nov 1, 1937
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References (21)

Publisher
American Medical Association
Copyright
Copyright © 1937 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1937.01480050105014
Publisher site
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Abstract

Abstract The proper selection of a blood donor necessitates not only tests for compatibility of blood and physical examinations but also, immediately before the transfusion, a very sensitive blood test for syphilis to prevent the transmission of this disease. The Kline exclusion slide test is an excellent method for this purpose, even in emergency cases, because of the rapidity, simplicity and ease of its performance and its high degree of sensitivity. Fifty-nine cases1 in which syphilis has been transmitted by donors are already recorded in medical literature! The actual number is probably much greater. In most of the cases reported serologic and physical examinations of the donors either were not made at all or else were not made within from three to twelve weeks prior to the transfusion. Professional donors, especially those used in cases of emergency, usually fall in the latter category, while voluntary donors, especially friends and relatives, References 1. Jones, H. W.; Rathmell, T. K., and Wagner, C.: The Transmission of Syphilis by Blood Transfusion , Am. J. Syph. & Neurol. 19:30-38 ( (Jan.) ) 1935. 2. Brem, W. V., in discussion on Griffin, H. Z., and Haines, S. F.: A Review of a Group of Professional Donors , J. A. M. A. 81:532 ( (Aug. 18) ) 1923. 3. Périn, L., and Lefèvre, M.: Transmission de la syphilis par voie sanguine , Nourrisson 23:371-374 ( (Nov.) ) 1935. 4. Mandelbaum, H., and Saperstein, A. N.: Transmission of Syphilis by Blood Transfusion: Case of Acute Gummatous Osteomyelitis , J. A. M. A. 106:1061-1063 ( (March 28) ) 1936. 5. Polayes, S. H., and Lederer, M.: The Transmission of Syphilis by Blood Transfusion , Am. J. Syph. 15:72-80 ( (Jan.) ) 1931. 6. Post, C. D., and Cooney, G. C.: Accidental Transmission of Syphilis by Blood Transfusion , J. A. M. A. 100:258-259 ( (Jan. 28) ) 1933. 7. Feldman, V. J.: Syphilis D'Emblée , Arch. Dermat. & Syph. 18:380-382 ( (Sept.) ) 1928. 8. Cummer, C. L.: Transfusion Syphilis , Am. J. M. Sc. 185:787-789 ( (June) ) 1933. 9. Morgan, H. J.: Factors Conditioning the Transmission of Syphilis by Blood Transfusion , Am. J. M. Sc. 189:808-813 ( (June) ) 1935. 10. Williamson, G. R., and Strong, R. A.: Congenital Syphilis from Blood Transfusion to the Mother During Pregnancy , Am. J. Syph. 17:484-491 ( (Oct.) ) 1933. 11. Hendrick, H.: Diseases Transmitted in Blood Transfusion , Proc. Inst. Med. Chicago 10:185-195 ( (Jan. 15) ) 1935. 12. Aubertin, C., and Fleury, J.: Syphilis après transfusion sanguine , Bull. et mém. Soc. méd. d. hôp. de Paris 54:69-75 ( (Jan. 27) ) 1930. 13. Martin, H. E., and Whyte, R.: Organization of Transfusion Service and Blood Donors Bureau for Average Hospital , Am. J. Surg. 32:439-444 ( (June) ) 1936. 14. Corwin, E. H. L.: Community Control of Professional Blood Donors , New York State J. Med. 35:317-320 ( (April 1) ) 1935. 15. Keynes, G.: The Technique of Blood Transfusion and the Organization of a Public Transfusion Service , J. State Med. 41:685-707 ( (Dec.) ) 1933. 16. Organization of Blood Donors in Germany, Foreign Letters , J. A. M. A. 105:610-611 ( (Aug. 24) ) 1935. 17. McNamara, W. L.: The Noninfectivity of the Blood in Tertiary Syphilis , Am. J. Syph. 9:470-478 ( (July) ) 1925. 18. Jones.1a Feldman.1g Cummer.1h Hendrick.1k 19. Eller, J. J., and Rein, C. R.: Kline Finger Blood Precipitation Test for Syphilis , Arch. Dermat. & Syph. 25:238-244 ( (Feb.) ) 1932. 20. Cumming, H. S.; Hazen, H. H.; Sanford, A. H.; Senear, F. E. M.; Simpson, W. M., and Vonderlehr, R. A.: The Evaluation of Serodiagnostic Tests for Syphilis in the United States , Ven. Dis. Inform. 16:189-201 ( (June) ) 1935 21. supp. 1, June 1935, pp. 1-49. 22. Kline, B. S.: Microscopic Slide Precipitation Tests for the Diagnosis and Exclusion of Syphilis , Baltimore, Williams & Wilkins Company, 1932. 23. Rein, C. R.: The Value of the Kline Exclusion Test in the Serodiagnosis of Syphilis , Am. J. Syph., Gonor. & Ven. Dis. 20:515-522 ( (Sept.) ) 1936. 24. Rein, C. R.: Personal communication to the author on the certification of blood donors in Jamaica, N. Y.

Journal

Archives of Dermatology and Syphilology – American Medical Association

Published: Nov 1, 1937

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