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BENIGN TYPE OF ACANTHOSIS NIGRICANS: ETIOLOGY

BENIGN TYPE OF ACANTHOSIS NIGRICANS: ETIOLOGY Abstract The association of acanthosis nigricans and cancer in a great number of cases is well known. This association occurs in 45 per cent of the patients with acanthosis nigricans, according to Mukai;1 in 45.3 per cent, according to Küttner,2 and in 54.5 per cent, according to Moncorps,3 who included cases of definite and probable cancer. The form of acanthosis nigricans which is associated with cancer is called malignant.4 Patients with the benign type of acanthosis nigricans do not suffer from cancer. This negative fact alone, not any difference in the macroscopic or histologic features of the two forms, determines the diagnosis of the benign type. It is true that only in one or two cases has the malignant form been observed in infancy or childhood and that it is the benign type which usually appears in early life, but no sharp division can References 1. Mukai, T.: Acta dermat. 14:460 ( (Nov.) ) 1929 2. 15:359 (April) 1930 3. abstr., Zentralbl. f. Haut- u. Geschlechtskr. 34:703, 1930. 4. Küttner, H.: Mitt. a. d. Grenzgeb. d. Med. u. Chir. 39:276, 1926. 5. Moncorps, C., in Jadassohn, J.: Handbuch der Haut- und Geschlechtskrankheiten , Berlin, Julius Springer, 1931, vol. 8, pt. (2) , p. 372. 6. Miescher, Guido: Dermat. Ztschr. 32:276 [ (April) ] 1921Crossref 7. Dr. Philip Lowenfish ( Acanthosis Nigricans [Juvenile Benign Form] , Arch. Dermat. & Syph. 29:763 [ (May) ] 1934) 8. at a meeting of the Section of Dermatology and Syphilis of the New York Academy of Medicine , in (November) 1933. 9. Of the staff of the Memorial Hospital. 10. Barendblat, J.: Med.-biol. j. 4:50, 1928; 11. Zentralbl. f. Haut-u. Geschlechtskr. 29:800, 1929. 12. Miescher, G.: Dermat. Ztschr. 32:276 ( (April) ) 1921. 13. Jadassohn, Werner: Arch. f. Dermat. u. Syph. 150:110, 1926. 14. Artom, Mario: Gior. ital. di dermat. e sif. 69:184, 1928. 15. Bodenstein, Erwin: Dermat. Wchnschr. 99:1670 ( (Dec. 29) ) 1934. 16. Berggreen, P.: Dermat. Wchnschr. 100:45 ( (Jan. 12) ) 1935. 17. Grace, Arthur W., and Schwartz, Hans J.: Acanthosis Nigricans , Arch. Dermat. & Syph. 29:691 ( (May) ) 1934. 18. Wieder, W. L. M.: Acanthosis Nigricans: Juvenile Type , J. A. M. A. 87:1964 ( (Dec. 11) ) 1926. 19. Knowles, F. C.; Sidlick, D. M., and Ludy, J. B.: Acanthosis Nigricans: Adult and Juvenile Types , Arch. Dermat. & Syph. 19:391 ( (March) ) 1929. 20. Burgess, Norman: Brit. J. Dermat. 43:169 ( (April) ) 1931. 21. Porias, J.: Wien. klin. Rundschau 27:671, 1913. 22. Mazzanti, Carlo: Dermosifilografo 8:453 ( (Sept.) ) 1933. 23. Kubo, Masaya, and Kohsaka, Masaichi: Kyoto-Ikadaigaku-Zasshi 10: 201, 1934. 24. Hellerström, Sven: Acta dermat.—venereol. 14:86 ( (June) ) 1933. 25. This suggestion is of interest in connection with the case reported in this paper, in which the symmetrical and generalized lesions developed at the beginning of puberty and subsided a few years later. 26. Kemeri, D.: Zentralbl. f. Haut- u. Geschlechtskr. 29:494, 1929. 27. Wile, U. J.: A Case for Diagnosis , Arch. Dermat. & Syph. 20:539 ( (Oct.) ) 1929. 28. Filser, H.: Monatsh. f. prakt. Dermat. 47:112, 1908. 29. de Moura Costa, Henrique: Ann. brasil de dermat. e syph. 1:47, 1925. 30. Spietschka, T.: Arch. f. Dermat. u. Syph. 44:247, 1898. 31. de Anduiza, J.: Rev. españ. de urol. y dermat. 26:303, 1924; 32. abstr., Zentralbl. f. Haut- u. Geschlechtskr. 14:376, 1925. 33. Mook, W. H.: Acanthosis Nigricans , Arch. Dermat. & Syph. 18:470 ( (Sept.) ) 1928. 34. Ludy, J. B.: Acanthosis Nigricans , Arch. Dermat. & Syph. 14:619 ( (Nov.) ) 1926. 35. Hitaka, M.: J. Orient. Med. 2:258, 1924. 36. Pautrier, L. M., and Hugel: Bull. Soc. franç. de dermat. et syph. 29:81, 1922. 37. Halty, A.; Delgado, B. C., and Volpé, A.: Rev. sud.-am. de méd. et de chir. 4:189 ( (March) ) 1933. 38. Sandbacker and Holmstroem: Zentralbl. f. Haut- u. Geschlechtskr. 53: 231, 1936. 39. Bernhardt, Robert: Przegl. dermat. 21:1, 1926; 40. abstr., Zentralbl. f. Haut- u. Geschlechtskr. 21:600, 1927; 41. Arch. f. Dermat. u. Syph. 170:533 ( (Nov.) ) 1934. 42. Bogrow, S. L.: Arch. f. Dermat. u. Syph. 94:271, 1909. 43. Darier, J.: Ann. de dermat. et syph. 4:865, 1893 44. 6:97, 1985 45. Besnier, E.; Brocq, L., and Jacquet, L.: Pratique dermatologique , Paris, Masson & Cie, 1900, vol. 1, p. 183. 46. Smith, Watson: Brit. J. Dermat. 45:142 ( (April) ) 1933. 47. Pick, cited by Moncorps.3 48. Kyrle, J.: Vorlesungen über Histo-Biologie der menschlichen Haut und ihrer Erkrankungen , Berlin, Julius Springer, 1927, vol. 1, p. 106. 49. Klotz, H. G., and Rohdenburg, G. L.: J. Cutan. Dis. 31:306 ( (May) ) 1913. 50. Hodara, M.: Monatsh. f. prakt. Dermat. 40:629, 1905 51. J. d. mal. cutan. et syph. 17:502 ( (July) ) 1905. 52. Kuznitzky, Martin: Arch. f. Dermat. u. Syph. 35:3, 1896.Crossref 53. Boeck, C.: Norsk. mag. f. lægevidensk. 12:273, 1897; 54. abstr., Arch. f. Dermat. u. Syph. 50:411, 1899. 55. Douglas, Heath: Proc. Roy. Soc. Med. 22:503 ( (Feb.) ) 1929. 56. Matras, August: Arch. f. Dermat. u. Syph. 174:12 ( (April) ) 1936.Crossref 57. Freund, E.: Rev. franç. de dermat. et de vénéréol. 7:450 ( (Sept.) ) 1931. 58. Petrini de Galatz: Ann. de dermat. et syph. 5:321, 1914. 59. Schlammadinger, Josef: Dermat. Wchnschr. 99:1257 ( (Sept. 29) ) 1934. 60. Michy, Jacques: L'acanthosis nigricans et ses rapports avec ces tumeurs malignes, monographiques sur les tumeurs , Laboratoire du Professeur Peyron , Institut Pasteur, Paris, E. Le François, 1932, vol. 13. 61. Schinz, Hans R., and Buschke, Franz: Krebs und Vererbung , Leipzig, Georg Thieme, 1935. 62. Among other instances the authors cited the following: Napoleon I and his father, a brother and two sisters died of gastric cancer. Warthin observed 63. Ewing ( Neoplastic Diseases , ed. 3, Philadelphia, W. B. Saunders Company, 1928) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

BENIGN TYPE OF ACANTHOSIS NIGRICANS: ETIOLOGY

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References (14)

Publisher
American Medical Association
Copyright
Copyright © 1936 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1936.01470150003001
Publisher site
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Abstract

Abstract The association of acanthosis nigricans and cancer in a great number of cases is well known. This association occurs in 45 per cent of the patients with acanthosis nigricans, according to Mukai;1 in 45.3 per cent, according to Küttner,2 and in 54.5 per cent, according to Moncorps,3 who included cases of definite and probable cancer. The form of acanthosis nigricans which is associated with cancer is called malignant.4 Patients with the benign type of acanthosis nigricans do not suffer from cancer. This negative fact alone, not any difference in the macroscopic or histologic features of the two forms, determines the diagnosis of the benign type. It is true that only in one or two cases has the malignant form been observed in infancy or childhood and that it is the benign type which usually appears in early life, but no sharp division can References 1. Mukai, T.: Acta dermat. 14:460 ( (Nov.) ) 1929 2. 15:359 (April) 1930 3. abstr., Zentralbl. f. Haut- u. Geschlechtskr. 34:703, 1930. 4. Küttner, H.: Mitt. a. d. Grenzgeb. d. Med. u. Chir. 39:276, 1926. 5. Moncorps, C., in Jadassohn, J.: Handbuch der Haut- und Geschlechtskrankheiten , Berlin, Julius Springer, 1931, vol. 8, pt. (2) , p. 372. 6. Miescher, Guido: Dermat. Ztschr. 32:276 [ (April) ] 1921Crossref 7. Dr. Philip Lowenfish ( Acanthosis Nigricans [Juvenile Benign Form] , Arch. Dermat. & Syph. 29:763 [ (May) ] 1934) 8. at a meeting of the Section of Dermatology and Syphilis of the New York Academy of Medicine , in (November) 1933. 9. Of the staff of the Memorial Hospital. 10. Barendblat, J.: Med.-biol. j. 4:50, 1928; 11. Zentralbl. f. Haut-u. Geschlechtskr. 29:800, 1929. 12. Miescher, G.: Dermat. Ztschr. 32:276 ( (April) ) 1921. 13. Jadassohn, Werner: Arch. f. Dermat. u. Syph. 150:110, 1926. 14. Artom, Mario: Gior. ital. di dermat. e sif. 69:184, 1928. 15. Bodenstein, Erwin: Dermat. Wchnschr. 99:1670 ( (Dec. 29) ) 1934. 16. Berggreen, P.: Dermat. Wchnschr. 100:45 ( (Jan. 12) ) 1935. 17. Grace, Arthur W., and Schwartz, Hans J.: Acanthosis Nigricans , Arch. Dermat. & Syph. 29:691 ( (May) ) 1934. 18. Wieder, W. L. M.: Acanthosis Nigricans: Juvenile Type , J. A. M. A. 87:1964 ( (Dec. 11) ) 1926. 19. Knowles, F. C.; Sidlick, D. M., and Ludy, J. B.: Acanthosis Nigricans: Adult and Juvenile Types , Arch. Dermat. & Syph. 19:391 ( (March) ) 1929. 20. Burgess, Norman: Brit. J. Dermat. 43:169 ( (April) ) 1931. 21. Porias, J.: Wien. klin. Rundschau 27:671, 1913. 22. Mazzanti, Carlo: Dermosifilografo 8:453 ( (Sept.) ) 1933. 23. Kubo, Masaya, and Kohsaka, Masaichi: Kyoto-Ikadaigaku-Zasshi 10: 201, 1934. 24. Hellerström, Sven: Acta dermat.—venereol. 14:86 ( (June) ) 1933. 25. This suggestion is of interest in connection with the case reported in this paper, in which the symmetrical and generalized lesions developed at the beginning of puberty and subsided a few years later. 26. Kemeri, D.: Zentralbl. f. Haut- u. Geschlechtskr. 29:494, 1929. 27. Wile, U. J.: A Case for Diagnosis , Arch. Dermat. & Syph. 20:539 ( (Oct.) ) 1929. 28. Filser, H.: Monatsh. f. prakt. Dermat. 47:112, 1908. 29. de Moura Costa, Henrique: Ann. brasil de dermat. e syph. 1:47, 1925. 30. Spietschka, T.: Arch. f. Dermat. u. Syph. 44:247, 1898. 31. de Anduiza, J.: Rev. españ. de urol. y dermat. 26:303, 1924; 32. abstr., Zentralbl. f. Haut- u. Geschlechtskr. 14:376, 1925. 33. Mook, W. H.: Acanthosis Nigricans , Arch. Dermat. & Syph. 18:470 ( (Sept.) ) 1928. 34. Ludy, J. B.: Acanthosis Nigricans , Arch. Dermat. & Syph. 14:619 ( (Nov.) ) 1926. 35. Hitaka, M.: J. Orient. Med. 2:258, 1924. 36. Pautrier, L. M., and Hugel: Bull. Soc. franç. de dermat. et syph. 29:81, 1922. 37. Halty, A.; Delgado, B. C., and Volpé, A.: Rev. sud.-am. de méd. et de chir. 4:189 ( (March) ) 1933. 38. Sandbacker and Holmstroem: Zentralbl. f. Haut- u. Geschlechtskr. 53: 231, 1936. 39. Bernhardt, Robert: Przegl. dermat. 21:1, 1926; 40. abstr., Zentralbl. f. Haut- u. Geschlechtskr. 21:600, 1927; 41. Arch. f. Dermat. u. Syph. 170:533 ( (Nov.) ) 1934. 42. Bogrow, S. L.: Arch. f. Dermat. u. Syph. 94:271, 1909. 43. Darier, J.: Ann. de dermat. et syph. 4:865, 1893 44. 6:97, 1985 45. Besnier, E.; Brocq, L., and Jacquet, L.: Pratique dermatologique , Paris, Masson & Cie, 1900, vol. 1, p. 183. 46. Smith, Watson: Brit. J. Dermat. 45:142 ( (April) ) 1933. 47. Pick, cited by Moncorps.3 48. Kyrle, J.: Vorlesungen über Histo-Biologie der menschlichen Haut und ihrer Erkrankungen , Berlin, Julius Springer, 1927, vol. 1, p. 106. 49. Klotz, H. G., and Rohdenburg, G. L.: J. Cutan. Dis. 31:306 ( (May) ) 1913. 50. Hodara, M.: Monatsh. f. prakt. Dermat. 40:629, 1905 51. J. d. mal. cutan. et syph. 17:502 ( (July) ) 1905. 52. Kuznitzky, Martin: Arch. f. Dermat. u. Syph. 35:3, 1896.Crossref 53. Boeck, C.: Norsk. mag. f. lægevidensk. 12:273, 1897; 54. abstr., Arch. f. Dermat. u. Syph. 50:411, 1899. 55. Douglas, Heath: Proc. Roy. Soc. Med. 22:503 ( (Feb.) ) 1929. 56. Matras, August: Arch. f. Dermat. u. Syph. 174:12 ( (April) ) 1936.Crossref 57. Freund, E.: Rev. franç. de dermat. et de vénéréol. 7:450 ( (Sept.) ) 1931. 58. Petrini de Galatz: Ann. de dermat. et syph. 5:321, 1914. 59. Schlammadinger, Josef: Dermat. Wchnschr. 99:1257 ( (Sept. 29) ) 1934. 60. Michy, Jacques: L'acanthosis nigricans et ses rapports avec ces tumeurs malignes, monographiques sur les tumeurs , Laboratoire du Professeur Peyron , Institut Pasteur, Paris, E. Le François, 1932, vol. 13. 61. Schinz, Hans R., and Buschke, Franz: Krebs und Vererbung , Leipzig, Georg Thieme, 1935. 62. Among other instances the authors cited the following: Napoleon I and his father, a brother and two sisters died of gastric cancer. Warthin observed 63. Ewing ( Neoplastic Diseases , ed. 3, Philadelphia, W. B. Saunders Company, 1928)

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Sep 1, 1936

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