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NONFATAL JAUNDICE ASSOCIATED WITH ARSPHENAMINE THERAPY: CLINICOPATHOLOGIC STUDY OF TWO CASES

NONFATAL JAUNDICE ASSOCIATED WITH ARSPHENAMINE THERAPY: CLINICOPATHOLOGIC STUDY OF TWO CASES Abstract Not infrequently during or after arsphenamine therapy, visible jaundice develops rather suddenly in certain patients and within from a few days to several weeks terminates in clinical recovery. Because of the benign course of this jaundice, material for gross and histologic examination is practically unavailable. Most discussions, therefore, dealing with the etiology and morbid anatomy of the condition have been characterized by inferences drawn from clinical observations rather than by conclusions founded on pathologic data. We report the following two cases of nonfatal jaundice associated chronologically with arsphenamine therapy because in each instance we had the unusual opportunity of making adequate histologic studies of the liver. In case 1 the patient died from a bleeding peptic ulcer and ascending pyelonephritis four weeks after jaundice had disappeared from the skin and scleras. In case 2 material for biopsy of the liver was obtained during the height of icterus at laparotomy performed http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

NONFATAL JAUNDICE ASSOCIATED WITH ARSPHENAMINE THERAPY: CLINICOPATHOLOGIC STUDY OF TWO CASES

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Publisher
American Medical Association
Copyright
Copyright © 1935 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1935.01470050046007
Publisher site
See Article on Publisher Site

Abstract

Abstract Not infrequently during or after arsphenamine therapy, visible jaundice develops rather suddenly in certain patients and within from a few days to several weeks terminates in clinical recovery. Because of the benign course of this jaundice, material for gross and histologic examination is practically unavailable. Most discussions, therefore, dealing with the etiology and morbid anatomy of the condition have been characterized by inferences drawn from clinical observations rather than by conclusions founded on pathologic data. We report the following two cases of nonfatal jaundice associated chronologically with arsphenamine therapy because in each instance we had the unusual opportunity of making adequate histologic studies of the liver. In case 1 the patient died from a bleeding peptic ulcer and ascending pyelonephritis four weeks after jaundice had disappeared from the skin and scleras. In case 2 material for biopsy of the liver was obtained during the height of icterus at laparotomy performed

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Nov 1, 1935

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