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NOTES ON TWO UNUSUAL CASES OF DARIER'S DISEASE

NOTES ON TWO UNUSUAL CASES OF DARIER'S DISEASE Abstract So many instances of Darier's disease have been recorded in the past thirty years that the mere recital of the symptomatology and description of the histopathologic changes in new cases ceases to be of more than passing interest. All the literature relative to the disease throws not one ray of light on the obscure problem of its etiology; the entire question of causation is as much of an enigma today as it was between 1889 and 1891, when J. C. White, Morrow, Darrier and Thibault published reports of their cases. Referring to its etiology, Jadassohn said that in his opinion the disease belongs in the group of congenital anomalies of cornification, and that it may occur in combination with various anomalies in the same individual, or may occur in the same family. In 1916, Boeck, in demonstrating some patients before the dermatologic congress in Christiania, stated that these individuals are References 1. This observation certainly does not accord with my experience. I have seen eight cases, none of which conveyed the impression of being mentally deficient (F. W.). 2. Morris, Malcolm: Internal Secretions in Relation to Dermatology , Brit. M. J. 1:1037 ( (May 17) ) 1913.Crossref 3. Strandberg, James: Beitrag zur Frage der Bedeutung der inneren Sekretion in der Dermatologie , Stockholm: Isaac Marcus, 1917. 4. Macleod, J. M. H.: Hormones in Relation to Diseases of the Skin , Practitioner 94:298 ( (Feb.) ) 1915. 5. Bulkley, L. Duncan: Psorospermosis Follicularis Cutis , Med. News ( (Nov. 8) ) 1890. 6. J. Cutan. & Genito-Urin. Dis. 9:7, 14, 1891. 7. We were informed by the patient's attending physician, Dr. B. F. Ochs, that he died only recently in New York of pneumonia. 8. Scheer, Max: A Case of Darier's Disease in Its Early Stages , J. Cutan. Dis. 34:837 ( (Dec.) ) 1916. 9. We had the opportunity of comparing the axillary lesions of acanthosis nigricans with these similarly situated patches of Darier's disease, and were unable to tell them apart by the naked eye; even palpation revealed no differences. 10. Drs. Fordyce and Pollitzer, who kindly examined these sections for us, confirmed the microscopic findings. 11. West Fifty-Ninth Street. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

NOTES ON TWO UNUSUAL CASES OF DARIER'S DISEASE

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References (4)

Publisher
American Medical Association
Copyright
Copyright © 1920 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1920.02350100018002
Publisher site
See Article on Publisher Site

Abstract

Abstract So many instances of Darier's disease have been recorded in the past thirty years that the mere recital of the symptomatology and description of the histopathologic changes in new cases ceases to be of more than passing interest. All the literature relative to the disease throws not one ray of light on the obscure problem of its etiology; the entire question of causation is as much of an enigma today as it was between 1889 and 1891, when J. C. White, Morrow, Darrier and Thibault published reports of their cases. Referring to its etiology, Jadassohn said that in his opinion the disease belongs in the group of congenital anomalies of cornification, and that it may occur in combination with various anomalies in the same individual, or may occur in the same family. In 1916, Boeck, in demonstrating some patients before the dermatologic congress in Christiania, stated that these individuals are References 1. This observation certainly does not accord with my experience. I have seen eight cases, none of which conveyed the impression of being mentally deficient (F. W.). 2. Morris, Malcolm: Internal Secretions in Relation to Dermatology , Brit. M. J. 1:1037 ( (May 17) ) 1913.Crossref 3. Strandberg, James: Beitrag zur Frage der Bedeutung der inneren Sekretion in der Dermatologie , Stockholm: Isaac Marcus, 1917. 4. Macleod, J. M. H.: Hormones in Relation to Diseases of the Skin , Practitioner 94:298 ( (Feb.) ) 1915. 5. Bulkley, L. Duncan: Psorospermosis Follicularis Cutis , Med. News ( (Nov. 8) ) 1890. 6. J. Cutan. & Genito-Urin. Dis. 9:7, 14, 1891. 7. We were informed by the patient's attending physician, Dr. B. F. Ochs, that he died only recently in New York of pneumonia. 8. Scheer, Max: A Case of Darier's Disease in Its Early Stages , J. Cutan. Dis. 34:837 ( (Dec.) ) 1916. 9. We had the opportunity of comparing the axillary lesions of acanthosis nigricans with these similarly situated patches of Darier's disease, and were unable to tell them apart by the naked eye; even palpation revealed no differences. 10. Drs. Fordyce and Pollitzer, who kindly examined these sections for us, confirmed the microscopic findings. 11. West Fifty-Ninth Street.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Oct 1, 1920

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