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CD8+Epidermotropic Cytotoxic T-Cell Lymphoma With Peripheral Blood and Central Nervous System Involvement

CD8+Epidermotropic Cytotoxic T-Cell Lymphoma With Peripheral Blood and Central Nervous System... OBSERVATION CD8 Epidermotropic Cytotoxic T-Cell Lymphoma With Peripheral Blood and Central Nervous System Involvement Camille E. Introcaso, MD; Ellen J. Kim, MD; Jennifer Gardner, MD; Jacqueline M. Junkins-Hopkins, MD; Carmela C. Vittorio, MD; Alain H. Rook, MD Background: Most cutaneous T-cell lymphomas dem- formed looking specifically at CD8 /CD4 cells in the pe- onstrate a malignant population with a CD4 pheno- ripheral blood and cerebrospinal fluid, a malignant popu- − − − type. In rare cases, CD8 phenotypes have been de- lation of CD8 /CD4 /CD26 /CD7 cells was discovered. scribed based on immunostaining of skin specimens. Although some CD8 lymphomas have an indolent Conclusions: It is important for prognosis and treat- course, others, such as CD8 epidermotropic cytotoxic ment to be able to identify CD8 epidermotropic cyto- T-cell lymphomas, are typically more aggressive. To our toxic T-cell lymphoma and separate it from other rela- knowledge, involvement of peripheral blood or cerebro- tively indolent CD8 lymphomas. Furthermore, detection − − spinal fluid with a malignant population of CD8 cells of an abnormal CD8 /CD26 /CD7 T-cell population demonstrated by flow cytometry and T-cell receptor gene within the peripheral blood has important prognostic and rearrangement has not been previously described. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Dermatology American Medical Association

CD8+Epidermotropic Cytotoxic T-Cell Lymphoma With Peripheral Blood and Central Nervous System Involvement

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References (10)

Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6068
eISSN
2168-6084
DOI
10.1001/archderm.144.8.1027
pmid
18711076
Publisher site
See Article on Publisher Site

Abstract

OBSERVATION CD8 Epidermotropic Cytotoxic T-Cell Lymphoma With Peripheral Blood and Central Nervous System Involvement Camille E. Introcaso, MD; Ellen J. Kim, MD; Jennifer Gardner, MD; Jacqueline M. Junkins-Hopkins, MD; Carmela C. Vittorio, MD; Alain H. Rook, MD Background: Most cutaneous T-cell lymphomas dem- formed looking specifically at CD8 /CD4 cells in the pe- onstrate a malignant population with a CD4 pheno- ripheral blood and cerebrospinal fluid, a malignant popu- − − − type. In rare cases, CD8 phenotypes have been de- lation of CD8 /CD4 /CD26 /CD7 cells was discovered. scribed based on immunostaining of skin specimens. Although some CD8 lymphomas have an indolent Conclusions: It is important for prognosis and treat- course, others, such as CD8 epidermotropic cytotoxic ment to be able to identify CD8 epidermotropic cyto- T-cell lymphomas, are typically more aggressive. To our toxic T-cell lymphoma and separate it from other rela- knowledge, involvement of peripheral blood or cerebro- tively indolent CD8 lymphomas. Furthermore, detection − − spinal fluid with a malignant population of CD8 cells of an abnormal CD8 /CD26 /CD7 T-cell population demonstrated by flow cytometry and T-cell receptor gene within the peripheral blood has important prognostic and rearrangement has not been previously described.

Journal

JAMA Dermatology – American Medical Association

Published: Aug 1, 2008

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