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What is atopic dermatitis and how should it be defined in epidemiological studies?
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EVIDENCE-BASED DERMATOLOGY: RESEARCH COMMENTARY Prevention of Atopic Eczema: A Dream Not So Far Away? Probiotics in primary prevention of atopic prick test reactions to milk, eggs, cats, and house dust disease: a randomised placebo-controlled trial mites were also measured in the children. Kalliomaki M, Salminen S, Arvilommi H, Kero P, The results among the 132 participants (83%) who Koskinen P, Isolauri E completed the study indicated that the frequency of diag- nosed atopic eczema in the probiotic group was half that Lancet. 2001;357:1076-1079 in the placebo group (15/64 [23%] vs 31/68 [46%]; rela- tive risk, 0.51; 95% confidence interval [CI], 0.32-0.84). Probiotics are cultures of potentially beneficial bacteria of This effect did not depend on whether the breastfeeding microflora of the healthy gut. Previous epidemiological mothers or the infants took the capsules. The number of studies that have suggested that there is an inverse rela- children who needed to be treated with the probiotics to tionship between infections and atopic disease. Kallio- prevent 1 extra case of atopic eczema was 5 (95% CI, 3-16). maki and colleagues proposed that specific microbes in Disease severity was very similar in both groups. Total IgE the commensal microflora of the gut during
JAMA Dermatology – American Medical Association
Published: Mar 1, 2002
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