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This Month in Archives of Dermatology

This Month in Archives of Dermatology Genomic Approaches to Skin Cancer Diagnosis Molecular pathology represents an exciting new arena of laboratory medicine, using genetic information to augment routine histopathologic diagnosis based on morphologic characteristics. With new therapeutic interventions available for the treatment of cutaneous malignancies, the need for more accurate, earlier diagnosis is becoming essential. In fact, failure to diagnose melanoma leads the list of malpractice claims among pathologists. However, even a meticulous histopathologic analysis based on refined morphological criteria does not always permit an unequivocal diagnosis. Bastian et al review some of the molecular techniques that have the potential to play a decisive role in the diagnosis of histologically ambiguous cutaneous tumors. See Article Molecular Diagnosis of Skin-Associated Infectious Agents Molecular pathologic assays augment those of classic laboratory medicine by providing additional diagnostic data more quickly or by providing results that would be unobtainable using standard methods. Payne et al review the molecular methods used to detect infectious agents of the cutaneous and mucosal epithelium. These methods offer rapid, highly sensitive detection of even minute numbers of infectious agents, some of which are not able to be cultured. See Article Clinical Genetics of Familial Keloids Keloids are proliferative fibrous growths that result from an excessive tissue response to skin trauma. Most keloids occur sporadically, but some cases are familial. Marneros et al, in the most compreshensive collection of keloid families to date, studied the clinical and genetic characteristics of 14 pedigrees with familial keloids, revealing an autosomal dominant mode of inheritance. View LargeDownload See Article The Genetics of Atopy and Atopic Eczema A genetic predisposition to the development of certain allergic disease was noted almost 100 years ago. The inheritance pattern of atopic disease is complex and does not follow the classic Mendelian patterns. MacLean and Eidelman review atopic disease-associated genes and discuss how improved diagnostic classification of atopic diseases, based on genotypic variants, could help direct appropriate therapeutic interventions. See Article The Genetics of Psoriasis 2001: The Odyssey Continues Mounting evidence indicates that psoriasis is caused by the combined action of multiple disease-associated genes in a single individual, often triggered by environmental factors. Elder et al review the evidence that psoriasis is a genetically inherited disease of skin and discuss the current state of knowledge regarding several putative psoriasis genes. These genes provide potential molecular targets for improved drug therapies. See Article Pharmacogenomics and Dermatological Therapeutics Understanding the structure and function of the human genome has allowed not only great advances in diagnosis, but also the potential to examine the interplay between genetics and individual reactions to drugs. Lowitt and Shear review the available genetic information related to drug toxic effects and drug efficacy. See Article http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

This Month in Archives of Dermatology

Archives of Dermatology , Volume 137 (11) – Nov 1, 2001
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This Month in Archives of Dermatology

Abstract

Genomic Approaches to Skin Cancer Diagnosis Molecular pathology represents an exciting new arena of laboratory medicine, using genetic information to augment routine histopathologic diagnosis based on morphologic characteristics. With new therapeutic interventions available for the treatment of cutaneous malignancies, the need for more accurate, earlier diagnosis is becoming essential. In fact, failure to diagnose melanoma leads the list of malpractice claims among pathologists. However, even...
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Publisher
American Medical Association
Copyright
Copyright © 2001 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.137.11.1410
Publisher site
See Article on Publisher Site

Abstract

Genomic Approaches to Skin Cancer Diagnosis Molecular pathology represents an exciting new arena of laboratory medicine, using genetic information to augment routine histopathologic diagnosis based on morphologic characteristics. With new therapeutic interventions available for the treatment of cutaneous malignancies, the need for more accurate, earlier diagnosis is becoming essential. In fact, failure to diagnose melanoma leads the list of malpractice claims among pathologists. However, even a meticulous histopathologic analysis based on refined morphological criteria does not always permit an unequivocal diagnosis. Bastian et al review some of the molecular techniques that have the potential to play a decisive role in the diagnosis of histologically ambiguous cutaneous tumors. See Article Molecular Diagnosis of Skin-Associated Infectious Agents Molecular pathologic assays augment those of classic laboratory medicine by providing additional diagnostic data more quickly or by providing results that would be unobtainable using standard methods. Payne et al review the molecular methods used to detect infectious agents of the cutaneous and mucosal epithelium. These methods offer rapid, highly sensitive detection of even minute numbers of infectious agents, some of which are not able to be cultured. See Article Clinical Genetics of Familial Keloids Keloids are proliferative fibrous growths that result from an excessive tissue response to skin trauma. Most keloids occur sporadically, but some cases are familial. Marneros et al, in the most compreshensive collection of keloid families to date, studied the clinical and genetic characteristics of 14 pedigrees with familial keloids, revealing an autosomal dominant mode of inheritance. View LargeDownload See Article The Genetics of Atopy and Atopic Eczema A genetic predisposition to the development of certain allergic disease was noted almost 100 years ago. The inheritance pattern of atopic disease is complex and does not follow the classic Mendelian patterns. MacLean and Eidelman review atopic disease-associated genes and discuss how improved diagnostic classification of atopic diseases, based on genotypic variants, could help direct appropriate therapeutic interventions. See Article The Genetics of Psoriasis 2001: The Odyssey Continues Mounting evidence indicates that psoriasis is caused by the combined action of multiple disease-associated genes in a single individual, often triggered by environmental factors. Elder et al review the evidence that psoriasis is a genetically inherited disease of skin and discuss the current state of knowledge regarding several putative psoriasis genes. These genes provide potential molecular targets for improved drug therapies. See Article Pharmacogenomics and Dermatological Therapeutics Understanding the structure and function of the human genome has allowed not only great advances in diagnosis, but also the potential to examine the interplay between genetics and individual reactions to drugs. Lowitt and Shear review the available genetic information related to drug toxic effects and drug efficacy. See Article

Journal

Archives of Dermatology – American Medical Association

Published: Nov 1, 2001

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