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Hepatitis C Virus–Related Skin Diseases

Hepatitis C Virus–Related Skin Diseases EDITORIAL HE HEPATITIS C virus (HCV) was identi- virus RNA sequences and HCV antibodies have been found fied 10 years ago thanks to research in mo- in sera and cryoprecipitates, more concentrated in cryo- lecular biology. At present, HCV infec- precipitates than in supernatants. By immunohistochemi- tion is a major public health problem in cal or in situ hybridization methods, HCV has been found T many countries, with the worldwide preva- in association with IgM and IgG in the cutaneous vascu- 12-14 lence of HCV markers ranging from from 0.1% to 5% (in- litic lesions of some patients. More often than not, type cluding 150 million chronic carriers). Infection be- I interferons have proven effective in treating cryo- comes chronic in 70% to 80% of cases and is complicated globulinemia and improving the results of liver function by cirrhosis within 20 years of contamination in about tests, which suggests a direct role for HCV in the devel- 15,16 20% of them. Once the cirrhotic process has begun, the opment of MC. On the other hand, in systemic vascu- incidence of hepatocellular carcinoma ranges from 1% litis, as in polyarteritis nodosa, HCV does not seem to play 17-19 to 4%. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Dermatology American Medical Association

Hepatitis C Virus–Related Skin Diseases

Doutre, Marie-Sylvie
JAMA Dermatology , Volume 135 (11) – Nov 1, 1999
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References (55)

Publisher
American Medical Association
Copyright
Copyright 1999 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6068
eISSN
2168-6084
DOI
10.1001/archderm.135.11.1401
Publisher site
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Abstract

EDITORIAL HE HEPATITIS C virus (HCV) was identi- virus RNA sequences and HCV antibodies have been found fied 10 years ago thanks to research in mo- in sera and cryoprecipitates, more concentrated in cryo- lecular biology. At present, HCV infec- precipitates than in supernatants. By immunohistochemi- tion is a major public health problem in cal or in situ hybridization methods, HCV has been found T many countries, with the worldwide preva- in association with IgM and IgG in the cutaneous vascu- 12-14 lence of HCV markers ranging from from 0.1% to 5% (in- litic lesions of some patients. More often than not, type cluding 150 million chronic carriers). Infection be- I interferons have proven effective in treating cryo- comes chronic in 70% to 80% of cases and is complicated globulinemia and improving the results of liver function by cirrhosis within 20 years of contamination in about tests, which suggests a direct role for HCV in the devel- 15,16 20% of them. Once the cirrhotic process has begun, the opment of MC. On the other hand, in systemic vascu- incidence of hepatocellular carcinoma ranges from 1% litis, as in polyarteritis nodosa, HCV does not seem to play 17-19 to 4%.

Journal

JAMA Dermatology – American Medical Association

Published: Nov 1, 1999

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