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EDITORIAL Human Herpesvirus 8 as the Infectious Cause of Kaposi Sarcoma Evidence and Involvement of Cofactors APOSI SARCOMA–ASSOCIATED human her- ized PEL-derived cell lines infected with HHV-8 are avail- pesvirus, or human herpesvirus 8 (HHV- able, no in vitro immortalization by HHV-8 has yet been 8), DNA sequences were first identified described. in 1994 using representational differ- As for other herpesviruses, 2 patterns of infection K ence analysis on Kaposi sarcoma (KS) and of host cells by HHV-8 can be distinguished: a latent phase healthy tissue from a patient seropositive for the human when the viral genome remains episomal for many rounds immunodeficiency virus (HIV). Until now, HHV-8 has of cell divisions and has limited gene expression and does been definitively associated with 3 human diseases: KS, not replicate, and a productive lytic phase. Three broad primary effusion lymphoma (PEL) (also called body cavi- classes of HHV-8 transcripts have been identified from a ty–based lymphoma), and multicentric Castleman dis- PEL-derived cell line. In this cell line class I genes, in- ease. cluding v-cyclin, the latency-associated nuclear antigen (LANA), and v-flip, are constitutively transcribed and un- See also pages 695 and 700 affected by inducers such as tetradecanoylphorbol ac- etate
JAMA Dermatology – American Medical Association
Published: Jun 1, 1998
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