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Erratum The effect of hypolipidaemic agents on peroxisomal β-oxidation and mixed-function oxidase activities in primary cultures of rat hepatocytes. Relationship between induction of palmitoyl-CoA oxidation and lauric acid hydroxylation
1. Daily treatment of female rats with butylated hydroxyanisole (BHA) protected against 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD) toxicity. This protective effect was associated with reduced microsomal lipid peroxidation, increased glutathione peroxidase (GSH-PX) activity and decreased aryl...
1. Lipophilic azo compounds possessing 1-phenylazo-2-naphthol or 1-phenylazo-2-naphthylamine moieties induced cytochrome P-448 and related mono-oxygenase activities, UDP-glucuronyltransferase activity towards p -nitrophenol, glutathione- S -transferase activity towards...
1. Glutathione- S -transferase (GST) from the liver cytosol of phenobarbital (PB)-treated rabbits was purified by DEAE-cellulose, CM-cellulose and hydroxylapatite column chromatography. 2. Four species of GST were obtained by eluting the CM-cellulose column with a linear KCl gradient, and the...
1. Rats were exposed by inhalation to low levels of diesel exhaust and/or coal dust, seven hours/day, five days/week for 24 months. 2. Cytochrome P-450-associated benzo( a )pyrene hydroxylase and 7-ethoxycoumarin deethylase activities were assayed in lung and liver microsomes after 3, 6, and 24...
1. Topical application of ellagic acid, a common plant phenol, to control or to 3-methylcholanthrene (3-MC) pretreated Balb/C mice, resulted in significant inhibition of hepatic and epidermal microsomal aryl hydrogen hydroxylase activity, and of benzo( a )pyrene (BP) binding to epidermal and...
1. Glutathione (GSH) transferase-mediated and non-enzymatic activation and detoxication of 3-hydroxyamino-1-methyl-5H-pyrido(4,3- b )indole (N-OH-Trp-P-2) were studied in vitro. N-OH-Trp-P-2 is an active metabolite of 3-amino-1-methyl-5 H -pyrido(4,3- b )indole (Trp-P-2), a mutagenic and...
1. Human- and rat-liver microsomes convert the lindane metabolite, β-PCCH (β-1,3,4,5,6-pentachlorocyclohex-1-ene (3,4,6/5-PCCH)) to the metabolites: 1,2,4-TCB (1,2,4-trichlorobenzene), 1,2,3,4-TTCB (1,2,3,4-tetrachlorobenzene), 2,4,5-TCP (2,4,5-trichlorophenol), 3,4,5/6-PCCOL...
1. Bromobenzene-3,4-oxide can be detected in venous blood of rats by trapping it as the corresponding 35 (S)glutathione conjugates. 2. More bromobenzene-3,4-oxide is detected in venous blood of rats treated with phenobarbital and diethyl maleate than in venous blood of rats treated with...
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