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1. In urine of rats treated with 1′, 2′-epoxyhexobarbital, unchanged compound and six metabolites were identified: 1,5-dimethylbarbituric acid, which is the end product of an epoxide-diol pathway, two stereochemically different 3′-hydroxy-1′,2′-epoxyhexobarbitals, a...
1. The disposition and metabolism of sulfinpyrazone have been studied in rats, guineapigs, rabbits, dogs, rhesus monkeys and miniature swine after intravenous administration of 100mg/kg of 14 C-labelled drug. 2. In all species, the integrated plasma concentration (AUC, 0-24h) of total...
1. After intravenous administration of the non-nutritive sweetener, saccharin (10mg/kg), to normal volunteers the plasma concentration-time curve fitted a two-compartment open model with a terminal half-life of 70 min. Renal clearance was high and the dose was recovered quantitatively in the...
1. The metabolism of 1,3-dibromopropane has been investigated in the rat. Two conjugated metabolites have been isolated from the urine and identified as S -(3-hydroxypropyl)cysteine and N -acetyl- S -(3-hydroxypropyl)cysteine. 2. An oxidation product, identified as β-bromolactic acid, has been...
1. A number of metabolites of oxapadol were isolated from urine of rat, dog and man after administration of a single dose of 14 C-labelled compound. They were identified by direct inlet mass spectrometry and chromatographic comparison with reference compounds. 2. Oxapadol was extensively...
1. Studies on the metabolism of 14 C-Michler's ketone (4,4′-bis-(dimethyl-amino)( carbonyl - 14 C)benzophenone) in rats have revealed that this carcinogen is subject to demethylation, ring-hydroxylation and N -acetylation after adjacent methyl groups have been removed. 2. As identified by mass...
1. The metabolism of the pesticide, 3,5-dibromosalicylanilide, has been studied, following oral administration to rats. 2. This compound is more toxic than other brominated salicylanilides, some fatalities being recorded at an oral dose of 100mg/kg. 3. 3,5-Dibromosalicylanilide is well absorbed,...
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