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1. On administration of a single oral dose of (4- 14 C)ethynodiol diacetate (0·15 mg/kg) to rhesus monkey, plasma concn. of total 14 C peaked after about 4 h. About 60% of the plasma radioactivity was present as glucuronide conjugates and no unchanged drug was detected. 2. Some 67 ±6% (mean ±...
1. Carcinogenic trans -4-dimethylaminostilbene and its unbound metabolites in rat tissues are highly lipophilic with partition coefficients of 10000 to 80 000. The values for bibenzyl derivatives are somewhat lower. 2. Sulphates and glucuronic acid conjugates are present in liver, kidney, blood...
1. Biliary elimination in female Wistar albino rats 3h after i.p. injection of ( 3 H)phenolphthalein, ( 3 H)morphine, 14 C-LSD and ( 14 C)diphenylacetic acid was 90%, 45%, 75% and 57% respectively, predominantly as glucuronides. 2. Infusion of 3 h bile from the previous experiments into the...
1. The disposition of a new β-blocking agent, chloropractolol, labelled with 14 C and with 3 H, has been studied in rats and mice. 2. After i.v. administration to the rat (25 mg/kg) of a mixture of ( 14 C)- and ( 3 H)chloropractolol, urinary and faecal excretion, biliary elimination and tissue...
1. Following single intramuscular doses of ( 14 C)fluprostenol (0·5-2·4μg/kg) to three female horses and to three gelded male horses, radioactivity was present in the plasma within 5 min; peak concn. (0·32-1·30 ng/ml fluprostenol equiv.) occurred 5 to 90 min after injection. Radioactivity...
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