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1. The pattern of conjugation of phenol and 1-naphthol was investigated in several primates; three Old World species (rhesus, cynomolgus, patas monkeys), two New World species (capuchin, tamarin), and two prosimians (bushbaby, tree shrew). 2. Following intra-muscular phenol or 1-naphthol...
1. Liver and kidney glutathione are depleted in rats and mice following administration of N -hydroxyparacetamol. 2. Centrilobular hepatic necrosis and necrosis of renal proximal convoluted tubules were also found, the liver lesion predominantly in mice and the renal lesion predominantly in rats....
1. Data from in vitro liver microsomal metabolism of ethylmorphine, aniline and benzpyrene in male rats and male and female quokkas ( Setonix Brachyurus ) were fitted to the Michaelis-Menten equation by Wilkinson's non-linear regression procedure and Eisenthal and Cornish-Bowden's direct linear...
1. After administration of styrene (I) to rat, three sulphur-containing urinary metabolites were isolated in the molar ratio of III: IV: V equal to 65: 34: 1. 2. These metabolites were identified as N -acetyl- S -(1-phenyl-2-hydroxy-ethyl)cysteine (III), N -acetyl- S...
1. After administration of (phthalidyl- 14 )talampicillin (Talpen® to rat. dog and man, radioactivity was excreted mainly in the urine (90%, 86% and 98% in rat, dog and man respectively). 2. After administration of (ampicillin- 14 C)talampicillin, radioactivity was excreted in the urine of rats...
1. 4-(2-Methyl-3-(4-chlorobenzoyl)phenyl)butanoic acid (RU 16029) is a potent anti-inflammatory and analgesic agent. In humans, its ketone group is rapidly reduced to an alcohol, whereas in rats, mice and dogs, its butanoic sidechain is rapidly oxidized to the corresponding acetic acid. 2. The...
1. 2,3,7,8-Tetrachlorodibenzo- p -dioxin (TCDD) was administered to rats to study its effects on the enzyme activities of the D-glucuronic acid pathway in the liver, small intestine and kidney. 2. The UDP-glucuronosyl transferase activity of male albino rats given TCDD (80 μg/kg, one dose, i.p.)...
1. The cis and trans isomers of the pancreatic carcinogen N -nitroso-2,6-dimethylmorpholine have been prepared separately, and their metabolism studied in the Syrian hamster. 2. Both isomers were metabolized by β-oxidation and ring scission to N -nitroso(2-hydroxypropyl)(2-oxopropyl)amine, the...
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