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1. 7-Chloro-4-(3′-diethylamino-4′-hydroxyanilino)quinoline (amodiaquine) labelled with 14 C has been synthesized and administered in single doses to rats including bile-duct-cannulated rats, to guinea-pigs and to mice, by oral or parenteral routes. 2. Amodiaquine was extensively and rapidly...
1. Following single oral doses (50 mg/kg) of 3-(γ-morpholino-β-3′,4′,5′-trimethoxybenzoxypropyl)-4-methyl-7,8-dimethoxy(4- 14 C)courmarin hydrochloride (ABBOTT-37624) to female New Zealand white rabbits, the major metabolite found in urine and faeces was the 7-O-demethylated,...
1. Optimum conditions for metabolism in vitro of p -xylene by rabbit liver or lung microsomal enzymes have been studied. Reactions were linear with time for at least 30 min at a microsomal protein concentration of 1 mg/ml. Addition of cytosol fraction to incubation mixtures of microsomes, NADPH,...
1. The fate of ( 14 C)rimiterol given orally, by aerosol, and intravenously to asthmatic patients has been investigated. 2. Following oral dosage (10 mg) < 50% dose was excreted in the urine. Two peaks in plasma concn. were seen, at 1–2 h and 3–5 h after dosing. Plasma radioactivity due to...
1. Within 0–5 h after intraperitoneal administration of ( 14 C)hexachlorophene to rats, radioactivity appeared in the bile. Over 2.5–3.0 days, 31% and 47% of administered doses of 5 mg/kg and 10 mg/kg, respectively, were eliminated via this route. 2. Ligation of the bile-duct increased the...
1. The chemical instability of prazitone was reflected in urinary metabolites excreted by the rabbit. The compound rearranges in vivo to a mixture of isomeric 2-allophanoyl-2-phenyl-3-oxo-octahydroindolizidines, which were then hydroxylated in the indolizidinone ring. 2. The hydroxylated...
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