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Although hepatic steatosis is common in patients infected with HCV, the mechanisms leading to cellular triglyceride retention are obscure. A role for the Unfolded Protein Response (UPR) has been postulated, either through its activation or dysfunction. In this study we set out to investigate the...
Highlights ► fAPN and fDC-SIGN are receptors for FIPV in cell lines. ► The role of these receptors in infection of target cells was studied for both serotypes of FIPV. ► FIPV I infection of monocytes depends on fDC-SIGN. ► Most FIPV I particles already interact with fDC-SIGN at the plasma...
Highlights ► Puumala virus infection in Syrian hamsters resembles to that in the natural hosts. ► Virus RNA persisted until 70 days post infection in various organs. ► Virus antigen persisted until 56 days post infection in kidneys and adrenal glands. ► High level of antibody responses...
Highlights ► The complete genome sequence of a virulent duck enteritis virus (DEV), an alphaherpesvirus, is presented for the first time. ► A comparative analysis of DEV genome sequences is provided. ► Potential attenuating principles of DEV are presented.
Japanese encephalitis virus (JEV) requires the presence of an inexplicable cellular receptor on the surface of the host cell for its entry into the cell. The JEV envelope (E) protein has been shown to play an important role in attachment to cells. By using a widely accepted technique, virus...
The nonstructural protein P9-1 of Rice black streaked dwarf virus has been confirmed to accumulate in viroplasms, the putative sites of viral replication, in infected plants and insects. We transformed rice plants by introducing an RNA interference construct against the P9-1-encoding gene. The...
Highlights • Random inserts of a shrimp parvovirus is found in the genome of the shrimp. • Standard detection methods may give false positive results for IHHNV infection. • Genome walking revealed a viral insert linked to a host microsattelite-like fragment.
Highlights ► VLPs are essential virulence factors in some Drosophila parasitoids. ► VLPs of Leptopilina boulardi share biogenesis with VLPs of the heterotoma clade. ► Mature L. boulardi VLPs are stellate and are delivered into the host hemolymph. ► The center of L. boulardi VLPs is...
Highlights ► Human adenovirus species D type 37 (HAdV-D37) is an important cause of eye disease. ► Annotation revealed an open reading frame, CR1-γ, in the E3 transcription unit. ► CR1-γ is predicted to be an integral membrane protein. ► RNA expression kinetics suggest a role in late...
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