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We evaluated the results of a treatment protocol that consisted of neoadjuvant hormonal therapy followed by radical retropubic prostatectomy (RRP) for clinical stage T3 (cT3) prostate cancer. Sixty-six patients with cT3 prostate cancer underwent staging procedures that included metastatic work-up...
Reduced expression of the low-affinity p75 neurotrophin receptor (p75 NTR ) occurs in prostate epithelial cells during malignant transformation. Recent studies indicating that the p75 NTR can transduce signals that induce apoptosis suggest that diminished p75 NTR in transformed prostate cells may...