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Potassium channels represent the largest group of pore proteins regulating K + efflux from the K + -rich inner cell to the extracellular compartment, thereby inducing changes in the membrane potential. Activity is regulated either by voltage or calcium concentrations, thus the nomenclature of...
The long QT syndrome is an inherited cardiac arrhythmic disease that has been regarded as a purely electrical disease. However, sporadic reports have indicated that myocardial contraction abnormalities are present in these patients. Novel echocardiographic techniques such as strain...
Half of heart failure patients have diastolic heart failure, which has no effective treatments. Several studies indicate a role for ω-3 polyunsaturated fatty acids (PUFAs) in heart failure. Recent studies suggest that ω-3 PUFAs inhibit cardiac fibrosis and attenuate diastolic dysfunction. This...
Surgical treatments for vascular disease have progressed during the past century from autologous bypass conduits to synthetic materials, animal-derived tissues, cryopreserved grafts, and, finally, bioengineered conduits. In all cases, alternative vascular grafting materials have been developed...
In chronic heart failure, maladaptive remodeling of the left ventricle (LV) with systolic and diastolic dysfunction underlies the inability of the heart to pump sufficient blood to supply the body with blood and oxygen. Three integral aspects of this maladaptive LV remodeling are (1) defects in...
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