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The Tufts Center for the Study of Drug Development has collected data on the clinical and approval phases of the 26 new biopharmaceuticals approved by the US Food and Drug Administration between 1980 and 1999. Here, the data for biopharmaceuticals approved between 1995 and 1999 are presented...
Interest in producing large quantities of supercoiled plasmid DNA has recently increased as a result of the rapid evolution of gene therapy and DNA vaccines. Owing to the commercial interest in these approaches, the development of production and purification strategies for gene-therapy vectors...
Liu, H. et al. (2000) Development of multichannel devices with an array of electrospray tips for high-throughput mass spectrometry. Anal. Chem. 72, 3303–3310 ( http://pubs.acs.org/journals/ancham/ )
This article discusses and documents the basic concepts of, and developments in, the field of optical nanosensors and nanobiosensors. It describes the progression of this field of research from its birth up to the present, with emphasis on the techniques of sensor construction and their...
Mitochondrial DNA (mtDNA) mutations underlie many rare diseases and might also contribute to human ageing. Gene therapy is a tempting future possibility for intervening in mitochondriopathies. Expression of the 13 mtDNA-encoded proteins from nuclear transgenes (allotopic expression) might be the...
Neto, E.D. et al. (2000) Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. Proc. Natl. Acad. Sci. U. S. A. 97, 3491–3496
Spiders make their webs and perform a wide range of tasks with up to seven different types of silk fiber. These different fibers allow a comparison of structure with function, because each silk has distinct mechanical properties and is composed of peptide modules that confer those properties. By...
A major goal of material science is to produce hierarchical materials that are ordered on all length scales, from the molecular (1–100 Å) via the nano (10–100 nm) to the meso (1–100 μm). In these materials, the larger-scale properties can be controlled by choosing molecular...
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