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ABSTRACT Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to cause gastrointestinal damage. New anti-inflammatory drugs have been developed in an attempt to improve their gastrointestinal side effect profile. Therefore, the objective of the present study was to compare the effect of three...
ABSTRACT Sustained high levels of circulating catecholamines may induce cardiotoxicity through oxidative mechanisms. Isoproterenol is a synthetic catecholamine with increasing attention owing to this application in cardiology. The aim of the present study was to investigate the cardioprotective...
ABSTRACT The protective effect of dendrodoine analog (DA) (4-amino-5-benzoyl-2-(4-methoxy phenylamino) thiazole) at three doses (5, 10, and 15 mg/kg body weight) was investigated on ethanol-induced hyperlipidemia. Hepatotoxicity was induced by administering 7.9 g ethanol/kg body weight for 45...
ABSTRACT In this research work we developed in vitro tests utilizing mammalian cell cultures, which can rapidly assess effect of exposure of oily sludge-derived chemicals on human and ecological health. Many of these are hazardous to health and environment due to their toxicity and/or...
ABSTRACT Investigations on the effects of diallyl disulphide (60 mg/kg body weight) orally administered (thrice a week) on the temporal patterns of thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase, and reduced glutathione (GSH) during N -Nitrosodiethylamine...
ABSTRACT Bisphenol A (BPA) (CAS Number 80–05-7; EINECS Number 201–245-8) is used in the production of plastics having food contact applications. Some biomonitoring studies have reported free BPA in blood or urine of humans. Since complete first-pass metabolism of orally administered BPA to...
ABSTRACT Phyllanthus niruri is a well-known hepatoprotective herbal plant. In the present study, hepatoprotective potential of the protein isolate of P. niruri was investigated against carbon tetrachloride (CCl 4 )-induced hepatoxicity in vitro. Isolated hepatocytes were treated with CCl 4 and...
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