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Assessment of the endocrine function in toxicology studies implies hormone determination in a number of animal species. Radioimmunoassay (RIA) constitutes the most widely used methodology for this purpose. RIA, however, presents important disadvantages inherent in the use of radiosotopes. In an...
Although biomicroscopy and indirect ophthalmoscopy remain the basis for studies in clinical ocular toxicology, evolving technologies, including fluorophotometry, Schiempflug photography, and electrophysiology of the visual system, are emerging as valuable tools in studying specific functions for...
A quantitative structure-activity relationship (QSAR) investigation was done for estimating the toxicity of organophosphorus compounds measured against midge larvae (Chironomus riparius) under varying temperature (11, 18, and 25°C) and pH (6, 7, and 8) conditions and with or without sediment....
Efforts are under way to develop a phenotypic analysis assay capable of identifying and differentiating chemicals with the potential to induce irritation and IgE-mediated and T-cell-mediated sensitization. These studies compare results obtained with the irritancy/phenotypic analysis assay to...
The authors have developed a method for optimizing nonlinear physiologically based pharmacokinetic (PBPK) models using Lagrangian-based or genetic algorithms. The optimization method is demonstrated using PBPK models for pharmacokinetics of nicotine, in which parameters that are not well...
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