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A method for relating mixture toxicity models and mechanisms of action has been developed. The approach utilizes a 1.2-factor matrix design to generate seven binary mixture concentration-response curves. The X 2 goodness-of-fit test is used to compare the experimental responses to the theoretical...
In an attempt to understand polysubstance abuse, and because little research has been performed regarding cocaethylene and genetic traits, the overall goal of this study was to determine if the hepatically synthesized metabolite of concurrent cocaine and ethanol administration, cocaethylene (CE),...
A novel automated computer imaging technique for assessing motor activity in rats to a standard acceptable for regulatory neurotoxicity studies is described. The Ethovision video tracking, motion analysis, and behavior recognition system is shown to reliably assess both increases and decreases in...