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Toxicological Sciences Volume Advance Article: April

Subject Areas: Toxicology
Publisher: Oxford University Press - Oxford University Press
ISSN: 1096-6080
SJR: 193

LitStream

Journal Article

Alcohol Metabolism in the Progression of Human Nonalcoholic Steatohepatitis

Li, Hui; Toth, Erica; Cherrington, Nathan J

2018 Toxicological Sciences

doi:10.1093/toxsci/kfy106 pmid:29718361

Abstract Alcohol metabolism is a well-characterized biological process that is dominated by the alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) families. Nonalcoholic steatohepatitis (NASH) is the advanced inflammatory stage of nonalcoholic fatty liver disease (NAFLD) and is known...
LitStream

Journal Article

Prenatal Exposure to DEHP Induces Neuronal Degeneration and Neurobehavioral Abnormalities in Adult Male Mice

Barakat, Radwa; Lin, Po-Ching; Park, Chan Jin; Best-Popescu, Catherine; Bakry, Hatem H; Abosalum, Mohamed E; Abdelaleem, Nabila M; Flaws, Jodi A; Ko, CheMyong

2018 Toxicological Sciences

doi:10.1093/toxsci/kfy103 pmid:29688563

Abstract Phthalates are a family of synthetic chemicals that are used in producing a variety of consumer products. Di-(2-ethylhexyl) phthalate (DEHP) is an widely used phthalate and poses a public health concern. Prenatal exposure to DEHP has been shown to induce premature reproductive senescence...
LitStream

Journal Article

Metabolism and Toxicity of Trichloroethylene and Tetrachloroethylene in Cytochrome P450 2E1 Knockout and Humanized Transgenic Mice

Luo, Yu-Syuan; Furuya, Shinji; Soldatov, Valerie Y; Kosyk, Oksana; Yoo, Hong Sik; Fukushima, Hisataka; Lewis, Lauren; Iwata, Yasuhiro; Rusyn, Ivan

2018 Toxicological Sciences

doi:10.1093/toxsci/kfy099 pmid:29897530

Abstract Trichloroethylene (TCE) and tetrachloroethylene (PCE) are structurally similar olefins that can cause liver and kidney toxicity. Adverse effects of these chemicals are associated with metabolism to oxidative and glutathione conjugation moieties. It is thought that CYP2E1 is crucial to...
LitStream

Journal Article

A Possible Novel Mechanism of Action of Genistein and Daidzein for Activating Thyroid Hormone Receptor-Mediated Transcription

Ariyani, Winda; Iwasaki, Toshiharu; Miyazaki, Wataru; Yu, Lu; Takeda, Shigeki; Koibuchi, Noriyuki

2018 Toxicological Sciences

doi:10.1093/toxsci/kfy097 pmid:29688519

Abstract Thyroid hormone receptors (TRs) are members of the nuclear receptor superfamily that regulate their target genes for controlling organ development and functional maintenance. Soybean isoflavones, especially genistein and daidzein, modulate various hormone-mediated pathways. However,...
LitStream

Journal Article

Effect of the Catechol-O-Methyltransferase Inhibitors Tolcapone and Entacapone on Fatty Acid Metabolism in HepaRG Cells

Grünig, David; Felser, Andrea; Duthaler, Urs; Bouitbir, Jamal; Krähenbühl, Stephan

2018 Toxicological Sciences

doi:10.1093/toxsci/kfy101 pmid:29688484

Abstract Tolcapone and entacapone are catechol-O-methyltransferase inhibitors used in patients with Parkinson’s disease. For tolcapone, patients with liver failure have been reported with microvesicular steatosis observed in the liver biopsy of 1 patient. We therefore investigated the impact of...
LitStream

Journal Article

Low Dose of Bisphenol A Modulates Ovarian Cancer Gene Expression Profile and Promotes Epithelial to Mesenchymal Transition Via Canonical Wnt Pathway

Hui, Lin; Li, Hongyi; Lu, Guang; Chen, Zhifeng; Sun, Wenjie; Shi, Yu; Fu, Zhiqin; Huang, Bo; Zhu, Xinqiang; Lu, Weiguo; Xia, Dajing; Wu, Yihua

2018 Toxicological Sciences

doi:10.1093/toxsci/kfy107 pmid:29718440

Abstract The xenoestrogen bisphenol A (BPA) is a synthetic endocrine disrupting chemical, having the potential to increase the risk of hormone-dependent ovarian cancer. Thus, a deeper understanding of the molecular and cellular mechanisms is urgently required in the novel cell models of ovarian...
LitStream

Journal Article

Chemotherapeutic Drugs Alter Functional Properties and Proteome of Mouse Testicular Germ Cells In Vitro

Karmakar, Polash Chandra; Cho, Yeon-Jin; Kim, Yong-Hee; Jung, Sang-Eun; Jin, Ju-Hee; Kim, Bang-Jin; Kwon, Woo-Sung; Kim, Young-Hyun; Pang, Myung-Geol; Ryu, Buom-Yong

2018 Toxicological Sciences

doi:10.1093/toxsci/kfy098 pmid:29733421

Abstract Many of the testicular cancer-survived patients, treated with chemotherapeutic drugs, show infertility, pre and postimplantation loss, and germ cell abnormality. Studies examining the negative effects of chemotherapeutic drugs on testicular germ cells are ongoing; however, information on...
LitStream

Journal Article

Aflatoxin B1 Disrupts Gut-Microbial Metabolisms of Short-Chain Fatty Acids, Long-Chain Fatty Acids, and Bile Acids in Male F344 Rats

Zhou, Jun; Tang, Lili; Wang, Jincheng; Wang, Jia-Sheng

2018 Toxicological Sciences

doi:10.1093/toxsci/kfy102 pmid:29897551

Abstract In this study, male F344 rats were orally exposed to aflatoxin B1 (AFB1) at 0, 5, 25, and 75 μg/kg for 4 weeks. Rat feces were collected from 2 to 4 weeks following exposure and were assessed for gut-microbiota-dependent metabolites. Gut-microbiota-related organic acids were quantitated...

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