Within the last year
Within the past 3 years
1 - 10 of 18 articles
Comparative studies of enzyme activities during the dedifferentiation of hepatic cells and through their development into overt hepatomas are few and contradictory. This study was designed to investigate the histochemical, biochemical and morphologic features of the altered liver cells with...
The preceeding paper described the origin and evolution of the pathology portion of carcinogen bioassays conducted under the direction of the National Cancer Institute (NCI) and subsequently by the National Toxicology Program (NTP). Review of 277 studies conducted under the NCI/NTP protocol...
Benzene hexachloride or hexachtorocyclohexane comes in eight isomeric forms which differ in the spatial positions of the chlorine atoms on the boat and chair forms. Only one, however, γ-isomer (lindane) possesses relevant insecticidal activity. The majority of studies on the potential...
Statistical issues related to the design, analysis and interpretation of carcinogenicity studies are considered. A proposed modification of the “standard” National Cancer Institute (NCI) design of carcinogenicity studies in rodents is discussed. The primary objective was to obtain a design...
Incorporation of mutagenicity tests in long term bioassays contributes relevant data for characterizing the oncogenic potential of a test compound. Additionally, genetic insult occurring in the germ cells may result in reproductive failure or the damage may be fixed as an inherited mutation with...
The results of subacute toxicity tests are the information most commonly used for setting doses for carcinogenicity studies. However, since diet composition is important in regard to tumor incidence, knowledge of the effect of various doses of the compound on the nutritional composition and...
Despite extensive research carried out over many years, a completely satisfactory method of testing drugs and chemicals for carcinogenicity continues to elude toxicologists. In the past, numerous scientific groups, regulatory agencies, and regional bodies have discussed and published specific...
Read and print from thousands of top scholarly journals.
Sign up with Facebook
Sign up with Google
Already have an account? Log in
Save this article to read later. You can see your Read Later on your DeepDyve homepage.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Sign Up Log In
To subscribe to email alerts, please log in first, or sign up for a DeepDyve account if you don’t already have one.
To get new article updates from a journal on your personalized homepage, please log in first, or sign up for a DeepDyve account if you don’t already have one.