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Comparative studies of enzyme activities during the dedifferentiation of hepatic cells and through their development into overt hepatomas are few and contradictory. This study was designed to investigate the histochemical, biochemical and morphologic features of the altered liver cells with...
The preceeding paper described the origin and evolution of the pathology portion of carcinogen bioassays conducted under the direction of the National Cancer Institute (NCI) and subsequently by the National Toxicology Program (NTP). Review of 277 studies conducted under the NCI/NTP protocol...
Benzene hexachloride or hexachtorocyclohexane comes in eight isomeric forms which differ in the spatial positions of the chlorine atoms on the boat and chair forms. Only one, however, γ-isomer (lindane) possesses relevant insecticidal activity. The majority of studies on the potential...
Statistical issues related to the design, analysis and interpretation of carcinogenicity studies are considered. A proposed modification of the “standard” National Cancer Institute (NCI) design of carcinogenicity studies in rodents is discussed. The primary objective was to obtain a design...
Incorporation of mutagenicity tests in long term bioassays contributes relevant data for characterizing the oncogenic potential of a test compound. Additionally, genetic insult occurring in the germ cells may result in reproductive failure or the damage may be fixed as an inherited mutation with...
The results of subacute toxicity tests are the information most commonly used for setting doses for carcinogenicity studies. However, since diet composition is important in regard to tumor incidence, knowledge of the effect of various doses of the compound on the nutritional composition and...
In the early 1970s the National Cancer Institute (NCI) initiated an animal bioassay program to determine if chemicals, to which the public are exposed, are hazardous by nature of their ability to induce cancer in animals. Experience with such tests led to the development of program guidelines in...
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