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Premature senescence may play an important role as an acute, drug-, or ionizing radiation (IR)-inducible growth arrest program along with interphase apoptosis and mitotic catastrophe. The aim of the study was to evaluate whether IR can induce senescence-like phenotype (SLP) associated with...
In this study, orbital gallium-67 citrate ( 67 Ga) scintigraphy was evaluated as a disease activity parameter that can predict the therapeutic response to immunosuppressive treatment in Graves' ophthalmopathy. Orbital scintigraphic analysis was performed on 32 patients demonstrating moderate to...
Selective thyromimetics have been designed and shown to exhibit some of the beneficial effects of thyroid hormones, such as lowering of cholesterol and weight reduction, without the adverse thyroid hormone action on muscle, bone, and heart rate. Progress has also been made in attempting to treat...
Mortality is low for young patients (younger than 21 years) with papillary thyroid cancer (PTC), and different mutations might contribute to this. Previous studies detected ret /PTC rearrangements more frequently in PTC from children than adults, and recent reports describe a high incidence of...
Steroid receptor coactivator-1 (SRC-1) interacts with nuclear hormone receptors (NRs) to mediate their action in a ligand-dependent manner. Among such ligands, thyroid hormone (TH) is particularly crucial for brain development. The expression of many TH target genes is regulated by TH only for a...
There is no doubt that the availability of recombinant human thyrotropin (rhTSH) is one of the milestones in the management of patients with differentiated thyroid cancer (DTC). It offers the opportunity to obtain representative serum thyroglobulin (Tg) levels and diagnostic whole-body scanning...
The high prevalence of celiac disease in patients with autoimmune hypothyroidism, compared to the general population, has been well documented but screening for celiac disease is not recommended as yet in otherwise asymptomatic hypothyroid patients. In recent years the high prevalence of...
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