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Basic fibroblast growth factor (bFGF) is a polypeptide with potent trophic effects on brain cells. In particular, bFGF promotes the survival and outgrowth of brain neurons, and protects neurons against toxic processes that are important contributors to cell death after cerebral ischemia (stroke)....
The migration of an autoreactive CD4 T lymphocyte across the blood-brain barrier (BBB) represents a crucial step in the pathogenesis of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalitis (EAE). For a naive, autoreactive T lym phocyte to enter the CNS, it must first...