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N termini of auxiliary β subunits that produce inactivation of large-conductance Ca 2+ -activated K + (BK) channels reach their pore-blocking position by first passing through side portals into an antechamber separating the BK pore module and the large C-terminal cytosolic domain. Previous work...
Pancreatic duct epithelium secretes a HCO 3 − -rich fluid by a mechanism dependent on cystic fibrosis transmembrane conductance regulator (CFTR) in the apical membrane. However, the exact role of CFTR remains unclear. One possibility is that the HCO 3 − permeability of CFTR provides a pathway...
Two processes dominate voltage-gated calcium channel (Ca V ) inactivation: voltage-dependent inactivation (VDI) and calcium-dependent inactivation (CDI). The Ca V β/Ca V α 1 -I-II loop and Ca 2+ /calmodulin (CaM)/Ca V α 1 –C-terminal tail complexes have been shown to modulate each,...
KirBac1.1 is a prokaryotic homologue of eukaryotic inward rectifier potassium (Kir) channels. The crystal structure of KirBac1.1 and related KirBac3.1 have now been used extensively to generate in silico models of eukaryotic Kir channels, but functional analysis has been limited to 86 Rb + flux...
The toxin produced by Bacillus anthracis , the causative agent of anthrax, is composed of three proteins: a translocase heptameric channel, (PA 63 ) 7 , formed from protective antigen (PA), which allows the other two proteins, lethal and edema factors (LF and EF), to translocate across a host...
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