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TRPM2 is a tetrameric Ca 2+ -permeable channel involved in immunocyte respiratory burst and in postischaemic neuronal death. In whole cells, TRPM2 activity requires intracellular ADP ribose (ADPR) and intra- or extracellular Ca 2+ , but the mechanism and the binding sites for Ca 2+ activation...
The large-conductance Ca 2+ -activated potassium (BK Ca ) channel of smooth muscle is unusually sensitive to Ca 2+ as compared with the BK Ca channels of brain and skeletal muscle. This is due to the tissue-specific expression of the BK Ca auxiliary subunit β1, whose presence dramatically...
The slow-channel congenital myasthenic syndrome (SCCMS) is a disorder of the neuromuscular junction caused by gain-of-function mutations to the muscle nicotinic acetylcholine (ACh) receptor (AChR). Although it is clear that the slower deactivation time course of the ACh-elicited currents plays a...
Voltage-gated potassium channels related to the Shal gene of Drosophila (Kv4 channels) mediate a subthreshold-activating current ( I SA ) that controls dendritic excitation and the backpropagation of action potentials in neurons. Kv4 channels also exhibit a prominent low voltage–induced...
CLC-ec1, a bacterial homologue of the CLC family’s transporter subclass, catalyzes transmembrane exchange of Cl − and H + . Mutational analysis based on the known structure reveals several key residues required for coupling H + to the stoichiometric countermovement of Cl − . E148 (Glu ex )...
Millimolar concentrations of the barbiturate pentobarbital (PB) activate γ-aminobutyric acid (GABA) type A receptors (GABARs) and cause blockade reported by a paradoxical current increase or “tail” upon washout. To explore the mechanism of blockade, we investigated PB-triggered currents of...
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