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In β cells, both glucose and hormones, such as GLP-1, stimulate production of the second messenger cAMP, but glucose and GLP-1 elicit distinct cellular responses. We now show in INS-1E insulinoma cells that glucose and GLP-1 produce cAMP with distinct kinetics via different adenylyl cyclases....
Connexin hemichannels are robustly regulated by voltage and divalent cations. The basis of voltage-dependent gating, however, has been questioned with reports that it is not intrinsic to hemichannels, but rather is derived from divalent cations acting as gating particles that block the pore in a...
Voltage-dependent calcium channels consist of a pore-forming subunit (Ca V α 1 ) that includes all the molecular determinants of a voltage-gated channel, and several accessory subunits. The ancillary β-subunit (Ca V β) is a potent activator of voltage-dependent calcium channels, but the...
The channel-forming component of anthrax toxin, (PA 63 ) 7 , is a heptameric water-soluble protein at neutral pH, but under acidic conditions it spontaneously inserts into lipid bilayers to form a 14-stranded β-barrel ion-conducting channel. This channel plays a vital role in anthrax...
The regulation of M-type (KCNQ Kv7) K + channels by phosphatidylinositol 4,5-bisphosphate (PIP 2 ) has perhaps the best correspondence to physiological signaling, but the site of action and structural motif of PIP 2 on these channels have not been established. Using single-channel recordings of...
We investigated the mechanism of synaptic suppression by P2Y receptors in mixed hippocampal cultures wherein networked neurons exhibit synchronized Ca 2+ oscillations (SCO) due to spontaneous glutamatergic synaptic transmission. Pharmacological studies suggested that SCO suppression was mediated...
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