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Small conductance calcium-gated potassium (SK) channels share an overall topology with voltage-gated potassium (K v ) channels, but are distinct in that they are gated solely by calcium (Ca 2+ ), not voltage. For K v channels there is strong evidence for an activation gate at the intracellular...
Two hybrid voltage-sensing systems based on fluorescence resonance energy transfer (FRET) were used to record membrane potential changes in the transverse tubular system (TTS) and surface membranes of adult mice skeletal muscle fibers. Farnesylated EGFP or ECFP (EGFP-F and ECFP-F) were used as...
Acetylcholine receptor channel gating is a propagated conformational cascade that links changes in structure and function at the transmitter binding sites in the extracellular domain (ECD) with those at a “gate” in the transmembrane domain (TMD). We used Φ-value analysis to probe the...
Acetylcholine receptor channel gating is a brownian conformational cascade in which nanometer-sized domains (“Φ blocks”) move in staggering sequence to link an affinity change at the transmitter binding sites with a conductance change in the pore. In the α-subunit, the first Φ-block to...
The epithelial Na + channel (ENaC) that mediates regulated Na + reabsorption by epithelial cells in the kidney and lungs can be activated by endogenous proteases such as channel activating protease 1 and exogenous proteases such as trypsin and neutrophil elastase (NE). The mechanism by which...
The inositol 1,4,5-trisphosphate (InsP 3 ) receptor (InsP 3 R) plays a critical role in generation of complex Ca 2+ signals in many cell types. In patch clamp recordings of isolated nuclei from insect Sf9 cells, InsP 3 R channels were consistently detected with regulation by cytoplasmic InsP 3...
Charged residues in the β10–M1 linker region (“pre-M1”) are important in the expression and function of neuromuscular acetylcholine receptors (AChRs). The perturbation of a salt bridge between pre-M1 residue R209 and loop 2 residue E45 has been proposed as being a principle event in the...
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