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Ca 2+ sparks are small, localized cytosolic Ca 2+ transients due to Ca 2+ release from sarcoplasmic reticulum through ryanodine receptors. In smooth muscle, Ca 2+ sparks activate large conductance Ca 2+ -activated K + channels (BK channels) in the spark microdomain, thus generating spontaneous...
“Funny” (f-) channels have a key role in generation of spontaneous activity of pacemaker cells and mediate autonomic control of cardiac rate; f-channels and the related neuronal h-channels are composed of hyperpolarization-activated, cyclic nucleotide–gated (HCN) channel subunits. We have...
Inward rectification in strong inward rectifiers such as Kir2.1 is attributed to voltage-dependent block by intracellular polyamines and Mg 2+ . Block by the polyamine spermine has a complex voltage dependence with shallow and steep components and complex concentration dependence. To understand...
Tumor cell membranes have multiple components that participate in the process of metastasis. The present study investigates the physical association of β1-integrins and Kv1.3 voltage-gated potassium channels in melanoma cell membranes using resonance energy transfer (RET) techniques. RET between...
Antidiuretic hormone and/or cAMP increase Na + transport in the rat renal collecting duct and similar epithelia, including Madin-Darby canine kidney (MDCK) cell monolayers grown in culture. This study was undertaken to determine if that increment in Na + transport could be explained...
Na + channel blockers such as flecainide have found renewed usefulness in the diagnosis and treatment of two clinical syndromes arising from inherited mutations in SCN5A, the gene encoding the α subunit of the cardiac voltage–gated Na + channel. The Brugada syndrome (BrS) and the LQT-3 variant...
The permeation pathway in voltage-gated potassium channels has narrow constrictions at both the extracellular and intracellular ends. These constrictions might limit the flux of cations from one side of the membrane to the other. The extracellular constriction is the selectivity filter, whereas...
Cysteine-scanning mutagenesis (SCAM) and computer-based modeling were used to investigate key structural features of the S6 transmembrane segment of the calcium-activated K + channel of intermediate conductance IKCa. Our SCAM results show that the interaction of 2-(trimethylammonium)ethyl...
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