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Sulfonamide chemotherapy was found to cure rats of an otherwise fatal form of experimental Friedländer's bacillus pneumonia when treatment was begun 6 hours after inoculation. Most of the pneumonic lesions cleared completely, but an occasional animal exhibited small residual abscesses in the...
1. The susceptibility of mice to the lethal effect of preparations containing the oxygen-labile hemolysin (streptolysin O) of group A hemolytic streptococci has been studied. Injection of a single sublethal dose of the streptococcal preparation causes the development of resistance to the effect...
Phagocytosis of encapsulated Friedländer's bacilli has been demonstrated in the lungs of rats in the absence of both circulating and local antibody. The mechanism of phagocytosis independent of antibody has been shown to be due to the same surface factors that operate in the phagocytosis of Type...
The course of pulmonary tuberculosis in the mouse appears to be accelerated as a result of concurrent infection of the lung with either of two pneumotropic viruses. This effect is obtained with virus inocula sufficiently small as to induce little or no definite viral pneumonia. Footnotes...
Transmission of the virus of St. Louis encephalitis to normal chickens by the bite of infected mites ( Dermanyssus gallinae ) has been demonstrated. Both experimentally infected and naturally infected mites were shown to be capable of transferring the virus of St. Louis encephalitis to chickens...
Serum albumin is a protective bacterial growth factor; by binding traces of fatty acid in the media it permits initiation of growth by the smallest possible inocula of tubercle bacilli. Each molecule of albumin binds 3 to 6 molecules of oleic acid (1 to 2 per cent of the weight of the albumin)...
Experimental pneumonia due to Friedländer's bacillus was produced in white rats by the intrabronchial inoculation of the bacilli suspended in mucin. The pneumonia was lobar in type, was almost uniformly fatal, and simulated the acute form of the natural disease in human beings. The pathogenesis...
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