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The mitochondrial ATPase inhibitor, IF 1 , regulates the activity of F 1 F o -ATPase. The inhibitory activity of IF 1 is highly pH-dependent. The effective inhibition by IF 1 requires a low pH. Under basic conditions, its activity markedly declines. The importance of His49 in the pH dependence of...
We have been interested in partially folded proteins with marginal stability and activity, because they have a potential to be mature proteins by artificial evolution. A module is defined as a contiguous peptide chain forming a compact region in a globular protein. Modules may be used as building...