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Ultra-high-molecular weight polyethylene (UHMWPE) wear, debris-induced osteolysis is a frequent cause of failure of total hip arthroplasty. Metal-on-metal total hip arthroplasty eliminates the generation of UHMWPE particulate debris. Although the volumetric wear of a metal-on-metal articulation...
The aim of this study was to establish a human macrophage cell culture system to examine the effect of polyethylene (PE) and titanium particles on cytokine release by macrophage-like cells (MLC) and to quantify this response with respect to the nature and concentration of particles. Human...
The generation of debris from the wear of ultra-high-molecular weight polyethylene (UHMWPE) is a well-recognized factor in the development of osteolysis and the long-term failure of total joint arthroplasties. Wear between the articulation of the femoral head and the polyethylene has been...
Aseptic loosening of the acetabular component remains a limiting factor in the long-term success of total hip replacement. An instrumented pressurizer has been designed to allow the intraoperative measurement of acetabular cement pressurization, which is known to contribute to implant fixation....
Although indomethacin is effective in preventing heterotopic ossification (HO) after total hip arthroplasty (THA) when used for 8 to 14 days, side effects are frequently observed. We conducted a prospective, nonrandomized pilot study of prophylaxis for HO in THA using indomethacin for 3 days. We...
Injury to the popliteal artery during total knee arthroplasty (TKA) is a devastating complication. Although infrequent, these injuries can result in the need for further surgery, including revascularization or possibly even amputation. Several mechanisms are capable of producing direct trauma to...
Distinguishing intracapsular and extracapsular hip infections may be clinically difficult. Because of this difficulty in diagnosis, the spread of an extracapsular infection into the hip joint may be missed and lead to significant joint destruction. The case of a patient who suffered from the...
Five patients with Paget's disease localized to the acetabulum received cementless acetabular components during total hip replacement. Three were primary surgeries, and 2 were revisions of a failed cemented acetabular component. At an average of 5.8 years (range, 4.8-8.8 years) after the...
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