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Background: To assess the lipid-lowering effects and safety of atorvastatin and niacin in patients with combined hyperlipidemia or isolated hypertriglyceridemia. Methods: We performed a randomized, open-label, parallel-design, active-controlled, study in eight centers in the United States. We...
Hypercholesterolemia, particularly an elevated level of low-density lipoprotein (LDL) cholesterol, is an unarguably established risk factor for coronary artery disease (CAD). It is equally well established that lowering LDL cholesterol levels will decrease CAD-related morbidity and mortality in...
Background: The effect of transfusion of small amounts of packed red blood cells (PRBC) on serum chemistry values is not known. Methods: We studied 73 adult patients without evidence of bleeding who received 2-unit PRBC transfusions. In study 1 (n = 39), we examined multiple laboratory values...
The benefits of cholesterol lowering for primary and secondary prevention of coronary artery disease (CAD) have been well established. However, to accurately assess a patient’s risk for CAD, clinicians must be aware of their patients’ specific levels of low-density lipoprotein (LDL)...
Purpose: Our 12-week internal medicine clerkship contains an 8-week inpatient and a 4-week outpatient component. This study examines the differences between these components, comparing diagnoses seen, category of learning, and student contribution to patient care. Methodology: Students used...
Emerging evidence is redefining traditional concepts of coronary atherosclerosis. Recent data indicate that severe stenoses, the traditional focus of attention, do not cause most coronary events. Rather, interest has increased in the often less stenotic but more vulnerable lesions that are...
Atherosclerotic vascular disease is the major cause of death and disability in adult men and women living in the United States, where 13–14 million adults have a history of coronary artery disease (CAD). One-third of the 1.5 million individuals who experience a myocardial infarction (MI) each...
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