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The Dutch Björk-Shiley convexo-concave (BScc) cohort serves as a reference population on the risk of outlet strut fracture and is being used to formulate guidelines for prophylactic replacement. Fractures, however, may be undetected at death. The aim of this study was to quantify the degree of...
We performed a multicenter, open-label study to determine the long-term safety and efficacy of a new extended-release once-a-night niacin preparation, Niaspan, in the treatment of hypercholesterolemia. Niaspan, 0.5 to 3.0 g once a night at bedtime, was used alone or in combination with a statin...
Coronary artery endothelial dysfunction has been proposed as a cause of myocardial ischemia and symptoms in patients with angina-like chest pain despite normal coronary angiograms, especially those with ischemic-appearing ST-segment depression during exercise (syndrome X). We measured coronary...
Convincing clinical trial evidence shows that lipid-lowering therapy can be effective in primary and secondary prevention of coronary artery disease events. At least 2 studies indicate that this benefit extends to persons with only mild or moderate hypercholesterolemia. The benefits of...
In the management of unstable angina and non–Q-wave acute myocardial infarction (AMI), there is considerable debate regarding the use of invasive strategy versus conservative strategy. The Thrombolysis In Myocardial Infarction (TIMI) III B trial found similar clinical outcomes for the 2...
To describe the epidemiology of nosocomial infections in Coronary Care Units (CCUs) in the United States, we analyzed data collected between 1992 and 1997 using the standard protocols of the National Nosocomial Infections Surveillance (NNIS) Intensive Care Unit (ICU) surveillance component. Data...
Little doubt remains about the value of lipid-lowering therapy since publication of the results of large, randomized, controlled trials that show decreased total, as well as coronary, mortality with the use of statins for primary and secondary prevention of coronary artery disease. All of the...
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