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A major reason for the relatively low sensitivity of Holter electrocardiography (ECG) for detecting ischemia is that the sensitivity of bipolar leads used for Holter ischemia monitoring has not been systematically evaluated, making lead selection difficult. Therefore, this study evaluated the...
Some antiarrhythmic drugs have been shown to influence the circadian pattern of sudden cardiac death (SCD). The effect of chronic amiodarone therapy on this pattern is unknown. This study determines the circadian pattern of deaths in the Congestive Heart Failure-Survival Trial of Antiarrhythmic...
We prospectively assessed whether baseline central hemodynamics and exercise capacity can predict improvement of V̇O 2 at ventilatory threshold (VT) after exercise training in patients with severe chronic congestive heart failure. Eighteen patients (mean ± SEM; age 52 ± 2 years), half of them...
The efficacy of aerobic exercise for lowering arterial blood pressure (BP) in postmenopausal women with elevations of 130 to 159/85 to 99 mm Hg has not been established. To determine this, 10 postmenopausal women with high normal resting BP or stage I essential hypertension were studied...
This study demonstrates that in CHF, altering the amount and type of the exercising muscle can change the ventilatory response to exercise. Signals emanating from skeletal muscle may contribute to the abnormal ventilatory response to exercise seen in CHF.
Rescue percutaneous transluminal coronary angioplasty (PTCA) has been used to establish reperfusion after failed thrombolysis, and the goal of this study was to examine the angiographic and clinical outcomes after rescue PTCA performed for an occluded artery 90 minutes after thrombolysis. Four...
In this prospective randomized multicenter trial comparing the stiff shaft Terumo glide wire with the conventional fixed-core straight metal guidewire for crossing of severely stenotic aortic valves, the use of the glide wire was the sole correlate of lower mean fluoroscopy time and crossover...
In this investigation, there was no appreciable effect on LDL particle diameter and there was no greater or lesser effect in patients classified at baseline as LDL pattern A, B, or I. This investigation indicates that fluvastatin, a 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitor, can...
Submaximal exercise tests have been advocated to assess exercise capacity in chronic heart failure, but hemodynamic responses have not been characterized. To determine left ventricular (LV) responses during submaximal exercise, the LV ejection fraction (EF) and volumes were evaluated by using an...
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