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We found that a fungus Neosartorya sp. produced an angiogenesis inhibitor, RK-805. By spectroscopic analyses and semi-synthetic methods from fumagillin, the structure of RK-805 was identified as 6-oxo-6-deoxyfumagillol, which has not been reported as a natural product. RK-805 preferentially...
A novel modulator of multidrug resistance (MDR) in tumor cells, kendarimide A ( 1 ), was isolated from an Indonesian marine sponge of Haliclona sp. Compound 1 reversed MDR in KB-C2 cells mediated by P-glycoprotein (P-gp) at a 6 μM concentration, and the chemical structure of 1 was characterized...
The hydrolysis of 2-phenylethyl β- d -glucopyranoside ( 3 ) was found to be partially inhibited by feeding with 2-phenyl- N -glucosyl-acetamidiumbromide ( 8 ), a β-glucosidase inhibitor, resulting in a decrease in the diurnal emission of 2-phenylethanol ( 2 ) from Rosa damascena Mill. flowers....
A detailed analysis of toxic shellfish collected in the Adriatic sea in October 2000 allowed us to isolate a new cytotoxic chlorosulfolipid ( 3 ). Its gross structure has been elucidated through an extensive NMR analysis including various 2D techniques; the relative stereochemistry has been...
Two new phlegmarane-type alkaloids, cermizines A ( 1 ) and B ( 2 ), three new quinolizidine alkaloids, cermizine C ( 3 ) and senepodines G ( 4 ) and H ( 5 ), and a new C 16 N 2 type alkaloid consisting of a quinolizidine and a piperidine ring, cermizine D ( 6 ), as well as two new cernuane-type...
Brine shrimp toxicity guided fractionation of the extracts from two mixed Fijian collections of the cyanobacteria Lyngbya majuscula and Schizothrix sp. led to the isolation of eleven novel chlorinated lipids. All of these metabolites show an intriguing constellation of unsaturation (olefinic and...
Climacostol ( 1 ), a defense toxin of the heterotrich ciliate Climacostomum virens was established as 5-( Z )-non-2-enyl-benzene-1,3-diol. The structure was rigorously confirmed by the total synthesis. The two congeners of climacostol contained in this ciliate were determined as 5-( Z , Z...
NF-κB is a transcription factor that induces inflammatory cytokines and anti-apoptotic proteins. We have designed a new NF-κB inhibitor based on the structure of the antibiotic epoxyquinomicin C. The designed compound, dehydroxymethylepoxyquinomicin (DHMEQ) was synthesized as a racemic form...
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