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Depression is a common and debilitating disorder linked to social adversity and stress. There have been many theories suggesting possible evolved functions of depression but few have explored evolved defensive mechanisms for coping with stressful events and how these may be compromised in human...
The effects of the ACTH (4-10) analogue, ACTH (4-7)-Pro-Gly-Pro, and delta-sleep inducing peptide (DSIP) on the induction of Fos immunoreactivity in the hypothalamic parvocellu-lar paraventricular nucleus (pPVN) and limbic brain regions were studied in Wistar rats with high (resistant) or low...
Striking similarities exist in the endocrinology of Cushing's disease and melancholic depression. Laboratory abnormalities, which have been found in both, include raised urinary, plasma and salivary Cortisol, non-suppression of Cortisol in the dexamethasone suppression test and...
Elevated basal plasma corticosterone concentrations have been observed for several days after the cessation of severe stress. In the present study, we examined whether or not the acute plasma corticosterone response to stress is necessary to elicit increased basal plasma corticosterone...
Urocortin, a member of the corticotropin releasing factor (CRF) peptide family, has a.45%sequence identity to CRF. Urocortin is ten-times more potent than CRF in increasing cAMP in cells expressing the CRF 2 receptor, therefore it was postulated to be an endogenous ligand for this receptor....
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