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Imaging prostate cancer continues to represent a clinical challenge for both primary and recurrent disease. In the evaluation of the persistent/recurrent/metastatic prostate cancer, knowledge of cancer location (local v distant), size, and extent are essential in order to design a treatment,...
For the last 60 years, hormonal therapy has been the cornerstone of treatment of metastatic prostate cancer. Unfortunately, hormonal therapy is purely palliative and improved systemic therapies are necessary. Monoclonal antibodies (mAbs) have proven valuable in the treatment of several diseases...
Recent results of several prospective phase II and phase III trials have reinforced the view that many patients with favorable-risk prostate cancer are overtreated. The challenge is to identify those patients who require treatment at a point at which they are still amenable to cure, and to avoid...
Given their novel mechanisms of action and relatively favorable toxicity profiles, differentiation agents have been the focus of much investigation in the field of oncology. Among the most well studied of these agents in prostate cancer have been the retinoids, vitamin D,...
Due to the generally indolent nature of prostate cancer, patients must decide among a wide range of treatments, which will significantly affect both quality of life and survival. Thus, there is a need for instruments to aid patients and their physicians in decision analysis. Nomograms are...
It is axiomatic that integrated multidisciplinary therapy based on the understanding of malignancy is required for the cure of adult cancer. In successful examples, agents (chemotherapy, biologics) and other modalities (radiation, surgery) are applied on the basis of clinical biology. The...
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