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Objective: To determine the clinical implications of the over‐expression of synovial and circulating interleukin (IL)‐23p19 and the correlation between IL‐23p19 and other cytokines such as IL‐17, tumour necrosis factor (TNF)ॅ, and IL‐1ॆ in rheumatoid arthritis (RA). Methods:...
Objectives: Rheumatoid arthritis (RA) is associated with increased cardiovascular disease (CVD) risk that has been attributed to endothelial dysfunction and inflammation. Non‐steroidal anti‐inflammatory drugs (NSAIDs) and cyclo‐oxygenase (COX)‐2 inhibitors have been shown in some studies...
Objective: Platelets are thought to participate in the pathogenesis of chronic inflammatory diseases such as rheumatoid arthritis (RA). We showed recently an in vivo increase in platelet–endothelial cell interactions in mice with antigen‐induced arthritis (AiA). The underlying mechanisms are...
Objective: To explore the cost of the statutory inpatient rehabilitation system in Finland and its impact on the functional and work capacity of patients with early rheumatoid arthritis (RA). Methods: In the Finnish Rheumatoid Arthritis Combination‐Therapy trial (FIN‐RACo), 195 patients with...
Objectives: To examine the association of the −173 single‐nucleotide G/C polymorphism of the macrophage migration inhibitory factor gene ( MIF ) and serum macrophage migration inhibitory factor (MIF) concentrations in a group of Italian patients with hereditary periodic fevers (HPF), tested...
Elevated levels of markers of nitric oxide (NO) production are found in osteoarthritic joints suggesting that NO is involved in the pathogenesis of osteoarthritis (OA). In OA, NO mediates many of the destructive effects of interleukin‐1 (IL‐1) and tumour necrosis factor‐ॅ (TNF‐ॅ) in...
Objective: To evaluate the prevalence, sensitivity, and specificity of anti‐chromatin and anti‐C1q antibodies in systemic lupus erythematosus (SLE) and lupus nephritis compared to small vessel vasculitis and other connective tissue diseases. To provide long‐term follow‐up data for...
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